| Identification | More | [Name]
2-(Trimethylsilyl)thiazole | [CAS]
79265-30-8 | [Synonyms]
2-THIAZOLYTRIMETHYLSILANE
2-TRIMETHYLSILANYL-THIAZOLE
2-(TRIMETHYLSILYL)-1,3-THIAZOLE
2-(TRIMETHYLSILYL)THIAZOLE
2-TST
2-Thiazolyltrimethylsilane
Thiazole, 2-(trimethylsilyl)-
2-（trimethyl)thiazole
2-TRIMETHYLSILYTHIAZOLE
Dondoni
2-Thiazolyltrimethylsilane, 2-TST | [Molecular Formula]
C6H11NSSi | [MDL Number]
MFCD00066274 | [Molecular Weight]
157.31 | [MOL File]
79265-30-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Boiling point ]
56-57 °C10 mm Hg(lit.) | [density ]
0.985 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.497(lit.)
| [Fp ]
135 °F
| [storage temp. ]
2-8°C
| [solubility ]
THF: very soluble(lit.) | [form ]
Liquid | [pka]
2.91±0.10(Predicted) | [color ]
Clear colorless to slightly yellow | [Specific Gravity]
0.99 | [Water Solubility ]
IMMISCIBLE | [Hydrolytic Sensitivity]
7: reacts slowly with moisture/water | [BRN ]
3538017 | [CAS DataBase Reference]
79265-30-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
1993 | [WGK Germany ]
3
| [F ]
10-21 | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29341000 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Physical properties]
bp 51–53 °C/10 mmHg; d 0.992 g mL?1; nD 1.4980. | [Uses]
2-(Trimethylsilyl)thiazole is used as formyl anion equivalent; effective one-carbon homologating reagent of alkoxy aldehydes, amino aldehydes, and
dialdoses.It takes part in the reactions of Homologation of Aldehydes, Metalation and Reactivity with Electrophiles, Cross-coupling Reactions, etc. | [Preparation]
Although 2-(trimethylsilyl)thiazole (1) is
commercially available, it can be easily prepared on a multigram scale from 2-bromothiazole, n-butyllithium, and chlorotrimethylsilane as shown in eq 1.
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