| Identification | More | [Name]
Propionyl chloride | [CAS]
79-03-8 | [Synonyms]
AKOS BBS-00004085
PROPANOYL CHLORIDE
PROPIONIC ACID CHLORIDE
PROPIONYL CHLORIDE
Propionyl chloride Propanoyl chloride
Propionic chloride
propionyl
Propionylchlorid
Propionylchloride,98%
Propanoylchlorid
Propionchloride
PROPIONYL CHLORIDE extrapure
Propanoic acid chloride | [EINECS(EC#)]
201-170-0 | [Molecular Formula]
C3H5ClO | [MDL Number]
MFCD00000745 | [Molecular Weight]
92.52 | [MOL File]
79-03-8.mol |
| Chemical Properties | Back Directory | [Appearance]
clear liquid | [Melting point ]
-94 °C | [Boiling point ]
77-79 °C (lit.) | [density ]
1.059 g/mL at 20 °C | [vapor density ]
3.2 (vs air)
| [vapor pressure ]
106 hPa (20 °C) | [refractive index ]
n20/D 1.404(lit.)
| [Fp ]
53 °F
| [storage temp. ]
Flammables area | [form ]
Liquid | [color ]
Clear | [PH Range]
<7.0 | [explosive limit]
3.6-11.9%(V) | [Water Solubility ]
REACTS | [FreezingPoint ]
-94℃ | [Sensitive ]
Moisture Sensitive | [Merck ]
14,7828 | [BRN ]
385632 | [Exposure limits]
ACGIH: TWA 0.1 ppm
OSHA: TWA 0.1 ppm(0.4 mg/m3)
NIOSH: IDLH 2 ppm; TWA 0.1 ppm(0.4 mg/m3); Ceiling 0.2 ppm(0.8 mg/m3) | [InChIKey]
RZWZRACFZGVKFM-UHFFFAOYSA-N | [Uses]
Chemical intermediate.
| [CAS DataBase Reference]
79-03-8(CAS DataBase Reference) | [NIST Chemistry Reference]
Propanoyl chloride(79-03-8) | [EPA Substance Registry System]
Propanoyl chloride (79-03-8) |
| Safety Data | Back Directory | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable.
R14:Reacts violently with water.
R34:Causes burns. | [Safety Statements ]
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1815 3/PG 2
| [WGK Germany ]
1
| [RTECS ]
UG6657000 | [Autoignition Temperature]
270 °C | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29051900 | [HS Code ]
29399990 | [Safety Profile]
A corrosive irritant to
skin, eyes, and mucous membranes.
Dangerous fire hazard when exposed to heat
or flame; can react vigorously with oxidizing
materials. Reacts with water or steam to
produce toxic and corrosive fumes.
Exothermic reaction with diisopropyl ether
produces much gas. The reaction may be
dangerous if confmed. To fight fire, use
CO2, dry chemical; do not use water. When
heated to decomposition it emits lughly
toxic fumes of Cl-. See also
HYDROCHLORIC ACID. | [Hazardous Substances Data]
79-03-8(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 823 mg/kg |
| Hazard Information | Back Directory | [General Description]
A colorless liquid with a pungent odor. Flash point of 50°F. Corrosive and very irritating to skin and eyes. Used to make other chemicals. | [Reactivity Profile]
Acid halides, such as PROPIONYL CHLORIDE(79-03-8), are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, and alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. | [Air & Water Reactions]
Highly flammable. Vigorously reacts with water to form propionic acid and hydrochloric acid [Merck 11th ed. 1989]. | [Hazard]
Strong irritant to skin.
| [Health Hazard]
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. | [Fire Hazard]
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. | [Chemical Properties]
clear liquid | [Application]
Propionyl chloride is used for the introduction of the propionyl group and for the synthesis of propionate esters because of its high reactivity. It is an chemical intermediate in the preparation of various propionic acid derivatives, It can also be used:
To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst.
For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.
In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose. | [Preparation]
Propionyl chloride is synthesized by reacting propionic acid with phosphorus trichloride at 40-50°C for 1h, cooling, standing, separating and distilling to obtain the product.
CH3CH2COOH+PCl3→CH3CH2COCl+HOPCl2
Propionyl chloride is industrially produced by chlorination of propionic acid with phosgene:
CH3CH2CO2H + COCl2 → CH3CH2COCl + HCl + CO2 | [Flammability and Explosibility]
Highlyflammable |
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