| Identification | More | [Name]
3-Ethyl-4-methyl-3-pyrrolin-2-one | [CAS]
766-36-9 | [Synonyms]
3-ETHYL-1,5-DIHYDRO-4-METHYL-2H-PYRROL-2-ONE
3-ETHYL-4-METHYL-1,5-DIHYDRO-2H-PYRROL-2-ONE
3-ETHYL-4-METHYL-1,5-DIHYDRO-PYRROL-2-ONE
3-ETHYL-4-METHYL-2-OXO-1,5-DIHYDROPYRROL-2-ONE
3-ethyl-4-methyl-2-oxo-3-pyrroline
3-ETHYL-4-METHYL-3-PYROLIN-2-ONE
3-ETHYL-4-METHYL-3-PYRROLIN-2-ONE
3-ETHYL-4-METHYL-3-PYRROLINE-2-ONE
3-Ethyl-4-methyl-3-pyrrolin-2-one98%
3-ETHYL-4-METHYL-2-OXO-3-PYROLINE
3-Ethyl-1,5-dihydro-4-methyl-2
3-ETHYL-4-METHYL-3-PYRROLIN-2-ONE/INTERMEDIATE OF GLIMEPIRIDE
3-ETHYL-4-METHYL-PYRROL-2-ONE 98+%
3-Ethyl-4-methyl-3-pyrrolin-2-one 98%
3-ETHYL-4-METHYL-2-OXO-1H-PYRROLIN | [EINECS(EC#)]
616-364-4 | [Molecular Formula]
C7H11NO | [MDL Number]
MFCD00173861 | [Molecular Weight]
125.17 | [MOL File]
766-36-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
100-104 °C (lit.) | [Boiling point ]
279.0±23.0 °C(Predicted) | [density ]
0.977±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
powder to crystal | [pka]
14.44±0.60(Predicted) | [color ]
White to Almost white | [Water Solubility ]
Slightly soluble in water. | [CAS DataBase Reference]
766-36-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29337900 |
| Hazard Information | Back Directory | [Uses]
3-Ethyl-4-methyl-3-pyrrolin-2-one is used as an intermediate for the manufacture of medicines. It is used for the preparation of Glimepiride (G410150), and its intermediates and as antidiabetic agents. | [General Description]
3-Ethyl-4-methyl-3-pyrrolin-2-one, a five-membered α,β-unsaturated lactam derivative, has various applications in medicinal chemistry. It can be synthesized by employing following as starting materials:
- allylamine, via palladium(II)-assisted cyclization
- 4-methoxybenzylamine, via a ring-closing-metathesis strategy
- 3-ethyl-1-(4-methoxybenzyl)-4-methyl-1,5-dihydro-2H-pyrrol-2- one
|
|
|