| Identification | Back Directory | [Name]
Methylophiopogonanone A | [CAS]
74805-92-8 | [Synonyms]
Methylophiopogonanone A
8-Methylophiopogonanone A
R-Methylophiopogonanone A
Methylophiopogonanone A (MO-A)
Methylophiopogonanone A(R-Methylophiopogonanone A)
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
(3R)-3-(1,3-Benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)- | [Molecular Formula]
C19H18O6 | [MDL Number]
MFCD11111461 | [MOL File]
74805-92-8.mol | [Molecular Weight]
342.34 |
| Chemical Properties | Back Directory | [Boiling point ]
580.1±50.0 °C(Predicted) | [density ]
1.410 | [storage temp. ]
2-8°C | [solubility ]
Soluble in chloroform and methanol; | [form ]
powder | [pka]
8.24±0.40(Predicted) | [color ]
Light yellow | [Water Solubility ]
insoluble in water |
| Hazard Information | Back Directory | [Description]
Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities.1,2,3,4 It increases the uptake of rosuvastatin (Item Nos. 12029 | 18813) and atorvastatin (Item No. 10493) in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC50s = 11.33 and 6 μM, respectively).2 Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays.1 In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia.3 It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery.4 | [Definition]
ChEBI: Methylophiopogonanone A is a homoflavonoid. | [target]
MMP(e.g.TIMP) |
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