| Identification | More | [Name]
N-Methyl-N-(trimethylsilyl)acetamide | [CAS]
7449-74-3 | [Synonyms]
MOUSE ALBUMIN
MSA
N-METHYL-N-TRIMETHYLSILYACETAMIDE
N-METHYL-N-TRIMETHYLSILYLACETAMIDE
N-TRIMETHYLSILYL-N-METHYLACETAMIDE
n-methyl-n-(trimethylsilyl)-acetamid
N-Methyl-N-trimethylsilyl-acetamide(MSA)
MSA~N-Trimethylsilyl-N-methylacetamide
N-Methyl-N-trimethylsilyacetamideMSA(N-Trimethylsilyl-N-methylacetamide)
N-Methyl-N-TMS-acetamide
N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent]
N-Methyl-N-trimethylsilylacetamine | [EINECS(EC#)]
231-217-0 | [Molecular Formula]
C6H15NOSi | [MDL Number]
MFCD00040758 | [Molecular Weight]
145.27 | [MOL File]
7449-74-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [F ]
10-21 | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29319090 |
| Hazard Information | Back Directory | [Chemical Properties]
clear light yellow liquid | [Uses]
N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:???????
- Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.???????
- Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.
| [Reactions]
The interaction of N-Methyl-N-(trimethylsilyl)acetamide with chloromethyl(methyl)-diacetoxysilane led to the formation of 2,4,6-trimethyl-2,4-bis((N-methylacetamido)methyl)-1,3,5,2,4-trioxadisilinan-6-ylium chloride[1].
| [General Description]
N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC). | [reaction suitability]
reagent type: derivatization reagent
reaction type: Silylations | [Purification Methods]
N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.] | [References]
[1] Nataliya F. Lazareva, Igor M.Lazarev,lrina V.Sterkhova. "Trans-silylationof N-methyl-N-trimethylsilylacetamide with chloromethyl(methyl)diacetoxysilane."Journal of Organometallic Chemistry1006 (2023): Article 123000.
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