| Identification | More | [Name]
1-Butanol | [CAS]
71-36-3 | [Synonyms]
AQUALINE STANDARD 10.0
1-Butyl alcohol
1-butylalcohol
1-Hydroxybutane
Alcool butylique
alcoolbutylique
alcoolbutylique(french)
butanol(french)
Butanol-1
Butanolen
Butanolo
butanols
butylalcohol(non-specificname)
Butylowy alkohol
butylowyalkohol
butylowyalkohol(polish)
Butyric alcohol
butyricalcohol
butyricornormalprimarybutylalcohol
CCS 203 | [EINECS(EC#)]
200-751-6 | [Molecular Formula]
C4H10O | [MDL Number]
MFCD08273554 | [Molecular Weight]
74.12 | [MOL File]
71-36-3.mol |
| Chemical Properties | Back Directory | [Description]
n-Butyl alcohol is a colourless flammable liquid with strong alcoholic odour. n-Butyl alcohol
is a highly refractive liquid and burns with a strongly luminous flame. It is incompatible
with strong acids, strong oxidising agents, aluminium, acid chlorides, acid anhydrides,
copper, and copper alloys. n-Butyl alcohol has an extensive use in a large number of industries.
For instance, it is used as solvent in industries associated with the manufacturing of
paints, varnishes, synthetic resins, gums, pharmaceuticals, vegetable oils, dyes, and alkaloids.
n-Butyl alcohol finds its use in the manufacture of artificial leather, rubber, plastic
cements, shellac, raincoats, perfumes, and photographic films. | [Appearance]
Colorless liquid | [Melting point ]
-90 °C (lit.) | [Boiling point ]
116-118 °C (lit.) | [density ]
0.81 g/mL at 25 °C(lit.)
| [vapor density ]
2.55 (vs air)
| [vapor pressure ]
6.7 hPa (20 °C) | [FEMA ]
2178 | [refractive index ]
n20/D 1.399(lit.)
| [Fp ]
95 °F
| [storage temp. ]
Store at RT. | [solubility ]
water: soluble | [form ]
Liquid | [pka]
15.24±0.10(Predicted) | [color ]
APHA: ≤10 | [Odor]
Alcohol-like; pungent; strong; characteristic; mildly alcoholic, non residual. | [PH]
7 (70g/l, H2O, 20℃) | [Relative polarity]
0.586 | [Stability:]
Stable. Incompatible with strong acids, strong oxidizing agents, aluminium, acid chlorides, acid anhydrides, copper, copper alloys. Flammable. | [biological source]
synthetic | [explosive limit]
1.4-11.3%(V) | [Odor Threshold]
0.038ppm | [Odor Type]
fermented | [Water Solubility ]
80 g/L (20 ºC) | [Sensitive ]
Moisture Sensitive | [λmax]
λ: 215 nm Amax: 1.00
λ: 220 nm Amax: 0.50
λ: 240 nm Amax: 0.10
λ: 260 nm Amax: 0.04
λ: 280-400 nm Amax: 0.01 | [JECFA Number]
85 | [Merck ]
14,1540 | [BRN ]
969148 | [Henry's Law Constant]
49.2 at 50 °C, 92.0 at 60 °C, 152 at 70 °C, 243 at 80 °C (headspace-GC, Hovorka et al., 2002) | [Dielectric constant]
17.1（25℃） | [Exposure limits]
TLV-TWA 300 mg/m3 (100 ppm) (NIOSH),
150 mg/m3 (50 ppm) (ACGIH); IDLH 8000
ppm (NIOSH). | [LogP]
0.88 | [CAS DataBase Reference]
71-36-3(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Butanol(71-36-3) | [EPA Substance Registry System]
71-36-3(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
n-Butyl alcohol is a colorless flammable liquid with a strong alcoholic odor. n-Butyl
alcohol is a highly refractive liquid and burns with a strongly luminous flame. It is
incompatible with strong acids, strong oxidizing agents, aluminium, acid chlorides,
acid anhydrides, copper, and copper alloys. n-Butyl alcohol has extensive use in a large
number of industries. For instance, it is used as a solvent in industries associated with
the manufacturing of paints, varnishes, synthetic resins, gums, pharmaceuticals, veg etable oils, dyes, and alkaloids. n-Butyl alcohol is used in the manufacture of artifi cial
leather, rubber, and plastic cements, shellac, raincoats, perfumes, and photographic
fi lms. | [General Description]
Colorless liquid. Used in organic chemical synthesis, plasticizers, detergents, etc. | [Reactivity Profile]
N-BUTYL ALCOHOL(71-36-3) attacks plastics. [Handling Chemicals Safely 1980. p. 236]. Mixtures with concentrated sulfuric acid and strong hydrogen peroxide can cause explosions. May form explosive butyl hypochlorite by reacting with hypochlorous acid. May form butyl explosive butyl hypochlorite with chlorine. | [Air & Water Reactions]
Highly flammable. Soluble in water. | [Hazard]
Toxic on prolonged inhalation, irritant to
eyes. Toxic when absorbed by skin. Flammable,
moderate fire risk. Eye and upper respiratory tract
irritant.
| [Health Hazard]
Anesthesia, nausea, headache, dizziness, irritation of respiratory passages. Mildly irritating to the skin and eyes. | [Health Hazard]
Exposures to n-butyl alcohol by inhalation, ingestion, and/or skin absorption are harm ful. n-Butyl alcohol is an irritant, with a narcotic effect and a CNS depressant. Butyl
alcohols have been reported to cause poisoning with symptoms that include, but are
not limited to, irritation to the eyes, nose, throat, and the respiratory system. Prolonged
exposure results in symptoms of headache, vertigo, drowsiness, corneal infl amma tion, blurred vision, photophobia, and cracked skin. It is advised that workers com ing in contact with n-butyl alcohol should use protective clothing and barrier creams.
Occupational workers with pre-existing skin disorders or eye problems, or impaired
liver, kidney or respiratory function may be more susceptible to the effects of the
substance. | [Potential Exposure]
Butyl alcohols are used as solvents for
paints, lacquers, varnishes, natural and synthetic resins,
gums, vegetable oils, dyes, camphor, and alkaloids. They
are also used as an intermediate in the manufacture of pharmaceuticals and chemicals; in the manufacture of artificial
leather, safety glass; rubber and plastic cements, shellac,
raincoats, photographic films, perfumes; and in plastic
fabrication.
| [Fire Hazard]
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. | [First aid]
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and
isolate contaminated clothing and shoes. In case of contact
with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact,
avoid spreading material on unaffected skin. Keep victim
warm and quiet. Effects of exposure (inhalation, ingestion
or skin contact) to substance may be delayed. Ensure that
medical personnel are aware of the material(s) involved
and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing
overexposure, as pulmonary edema may be delayed. As
first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy | [Shipping]
UN1120 Butanols, Hazard Class: 3; Labels: 3—
Flammable liquid. UN1212 Isobutanol or Isobutyl alcohol,
Hazard Class: 3; Labels: 3—Flammable liquid | [Incompatibilities]
Butyl alcohols may form explosive mixture with air. In all cases they are Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates,
perchlorates, chlorine, bromine, fluorine, etc.); contact may
cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks
some plastics, rubber and coatings. n-Butanol is incompatible with strong acids; halogens, caustics, alkali metals; aliphatic amines; isocyanates. sec-Butanol forms an explosive
peroxide in air. Ignites with chromium trioxide.
Incompatible with strong oxidizers; strong acids; aliphatic
amines; isocyanates, organic peroxides. tert-Butanol is
incompatible with strong acids (including mineral acid),
including mineral acids; strong oxidizers or caustics, aliphatic amines; isocyanates, alkali metals (i.e., lithium,
sodium, potassium, rubidium, cesium, francium). isoButanol is incompatible with strong acids; strong oxidizers;
caustics, aliphatic amines; isocyanates, alkali metals and
alkali earth. May react with aluminum at high temperatur | [Waste Disposal]
Incineration, or bury absorbed
waste in an approved land fill. | [Physical properties]
Clear, colorless liquid with a rancid sweet odor similar to fusel oil. Experimentally determined
detection and recognition odor threshold concentrations were 900 μg/m3 (300 ppbv) and 3.0 mg/m3
(1.0 ppmv), respectively (Hellman and Small, 1974). Odor threshold concentration in water is 500
ppb (Buttery et al., 1988). The least detectable odor threshold in concentration water at 60 °C was
0.2 mg/L (Alexander et al., 1982). Cometto-Mu?iz et al. (2000) reported nasal pungency threshold
concentrations ranging from approximately 900 to 4,000 ppm. | [Occurrence]
Reported present in peppermint oil from Brazil, Achillea ageratum, tea, apple aroma, American cranberry, black
currants, guava fruit, papaya, cooked asparagus, tomato, Swiss cheese, Parmesan cheese, heated butter, cognac, Armagnac, rum and cider. | [Definition]
ChEBI: A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes. | [Definition]
Two alcohols that are
derived from butane: the primary alcohol
butan-1-ol (CH3(CH2)2CH2OH) and the
secondary alcohol butan-2-ol
(CH3CH(OH)CH2CH3). Both are colorless
volatile liquids used as solvents. | [Production Methods]
The principal commercial source of 1-butanol is n-butyraldehyde
obtained from the oxo reaction of propylene,
followed by hydrogenation in the presence of a catalyst
. 1-Butanol has also been produced from
ethanol via successive dehydrogenation to acetaldehyde,
followed by an aldol process. The earliest commercial
route to 1-butanol, which is still used extensively
in many Third World countries, employs fermentation
of molasses or corn products with Clostridium acetobutylicum
. | [Aroma threshold values]
Detection: 500 ppb to 509 ppm | [Chemical Reactivity]
Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. | [Synthesis]
n-Butyl alcohol is obtained by fermentation of glycerol, mannite, starches, and sugars in general, using Bacillus butylicus
sometimes synergized by the presence of Clostridium acetobutryricum; synthetically, from acetylene. | [Source]
1-Butanol naturally occurs in white mulberries and papaya fruit (Duke, 1992). Identified
as one of 140 volatile constituents in used soybean oils collected from a processing plant that fried
various beef, chicken, and veal products (Takeoka et al., 1996). | [Environmental Fate]
2Biological. 1-Butanol degraded rapidly, presumably by microbes, in New Mexico soils releasing
carbon dioxide (Fairbanks et al., 1985). Bridié et al. (1979) reported BOD and COD values of 1.71
and 2.46 g/g using filtered effluent from a biological sanitary waste treatment plant. These values
were determined using a standard dilution method at 20 °C for a period of 5 d. Heukelekian and
Rand (1955) reported a similar 5-d BOD value of 1.66 g/g which is 64.0% of the ThOD value of
2.59 g/g. Using the BOD technique to measure biodegradation, the mean 5-d BOD value (mM
BOD/mM 1-butanol) and ThOD were 3.64 and 60.7%, respectively (Vaishnav et al., 1987). In
activated sludge inoculum, following a 20-d adaptation period, 98.8% COD removal was
achieved. The average rate of biodegradation was 84.0 mg COD/g?h (Pitter, 1976).
Photolytic. An aqueous solution containing chlorine and irradiated with UV light (λ = 350 nm)
converted 1-butanol into numerous chlorinated compounds which were not identified (Oliver and Carey, 1977).
Reported rate constants for the reaction of 1-butanol and OH radicals in the atmosphere: 6.8 x
10-10 cm3/molecule?sec at 292 K (Campbell et al., 1976), 8.31 x 10-12 cm3/molecule?sec
(Wallington and Kurylo, 1987). Reported rate constants for the reaction of 1-butanol and OH
radicals in the atmosphere: 8.3 x 10-12 cm3/molecule?sec at 298 K (Atkinson, 1990); with OH
radicals in aqueous solution: 2.2 x 10-9 L/molecule?sec (OH concentration 10-17 M) (Anbar and
Neta, 1967). Based on an atmospheric OH concentration of 1.0 x 106 molecule/cm3, the reported
half-life of 1-butanol is 0.96 d (Grosjean, 1997).
Chemical/Physical. Complete combustion in air yields carbon dioxide and water vapor. Burns
with a strongly luminous flame (Windholz et al., 1983).
1-Butanol will not hydrolyze because it has no hydrolyzable functional group (Kollig, 1993).
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent
concentration of 466 mg/L. The adsorbability of the carbon used was 107 mg/g carbon (Guisti et
al., 1974). | [Purification Methods]
Dry it with MgSO4, CaO, K2CO3, or solid NaOH, followed by refluxing with, and distillation from, small amounts of calcium, magnesium activated with iodine, or aluminium amalgam. It can also be dried with molecular sieves, or by refluxing with n-butyl phthalate or succinate. (For method, see Ethanol.) n-Butanol can also be dried by efficient fractional distillation, water passing over in the first fraction as a binary azeotrope (contains about 37% water). An ultraviolet-transparent distillate has been obtained by drying with magnesium and distilling from sulfanilic acid. To remove bases, aldehydes and ketones, the alcohol is washed with dilute H2SO4, then NaHSO4 solution; esters are removed by boiling for 1.5hours with 10% NaOH. It has also been purified by adding 2g NaBH4 to 1.5L butanol, gently bubbling with argon and refluxing for 1 day at 50o. Then adding 2g of freshly cut sodium (washed with butanol) and refluxed for 1day. Distil and collect the middle fraction [Jou & Freeman J Phys Chem 81 909 1977]. [Beilstein 1 IV 1506.] | [Toxicity evaluation]
The primary effects observed following oral and inhalation
exposure in rats and mice to n-butyl alcohol include neurological
and neurodevelopmental effects. n-Butyl alcohol has
been evaluated in a large number of experimental animal and
in vitro studies examining possible mechanisms for alcoholinduced
neurotoxicity. One proposed mechanism is that alcohols,
in general, produce neurological changes by disrupting
the lipid bilayer. A few experimental animal studies have
shown that n-butyl alcohol, like other alcohols, can disrupt
membrane integrity. Other in vitro and experimental animal
studies have demonstrated that n-butyl alcohol interacts with
protein-receptors and modulates their effects such that it
potentiates inhibitory g-aminobutyric acid (GABA) and glycine
receptors and inhibits excitatory neuronal receptors such
a glutamate. This modulatory action of n-butyl alcohol is
supportive of the observed neurobehavioral changes (e.g.,
central nervous system (CNS) depressant profile) associated
with n-butyl alcohol exposure in humans.
In addition, experimental animal studies have shown that
n-butyl alcohol inhibits fetal rat brain astroglial cell proliferation
by disrupting the phospholipase D (PLD) signaling
pathway. Inhibition of astroglial cell proliferation, which has
been postulated as a mode of action for ethanol-induced
microencephaly and mental retardation observed in cases of
fetal alcohol syndrome. These mechanisms can also be relevant
to the observed dilation in the brain that has been noted in
animals gestationally exposed to n-butyl alcohol. | [Toxics Screening Level]
The current ITSL for n-butanol (350 μg/m3) was established on July 22, 1992 (see attached). |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T,F | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R67:Vapors may cause drowsiness and dizziness.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S13:Keep away from food, drink and animal feeding stuffs .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S46:If swallowed, seek medical advice immediately and show this container or label .
S7/9:Keep container tightly closed and in a well-ventilated place .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
S7:Keep container tightly closed . | [OEL]
Ceiling: 50 ppm (150 mg/m3) [skin] | [RIDADR ]
UN 1120 3/PG 3
| [WGK Germany ]
1
| [RTECS ]
EO1400000
| [Autoignition Temperature]
649 °F | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29051300 | [storage]
Store n-butyl alcohol in a cool, dry, well-ventilated location, away from smoking areas.
Fire hazard may be acute. Outside or detached storage is preferred. Separate from
incompatibles. Containers should be bonded and grounded for transfer to avoid static
sparks | [Safety Profile]
: A poison by
intravenous route. Moderately toxic by skin
Review: Group 3 IMEMDT 7,56,87; Animal
Inadequate Evidence IMEMDT 39,67,86* contact, ingestion, subcutaneous, and
intraperitoneal routes. Human systemic Reported in EPA TSCA Inventory.
Community fight-To-Ihow List.
OSHA PEL: TWA 10 pprn
Classifiable as a Carcinogen
DFG MAK: 2 ppm (11 mg/m3)
DOT CLASSIFICATION: 3; Label:
Flammable Liquid
ingestion, inhalation, skin contact, and
intraperitoneal routes. Experimental
reproductive effects. A skin and eye irritant.
Questionable carcinogen. A flammable
fight fire, use foam, CO2, dry chemical.
Incompatible with oxidzing materials.
When heated to decomposition it emits
acrid and irritating fumes. See also ESTERS.
effects by inhalation: conjunctiva irritation,
unspecified respiratory system effects, and
nasal effects. Experimental reproductive
Though animal experiments have shown the
butyl alcohols to possess toxic properties,
they have produced few cases of poisoning
in industry, probably because of their low
reported to have resulted in irritation of the
eyes, with corneal inflammation, slight
headache and H2ziness, slight irritation of
the nose and throat, and dermatitis about
fingers. Keratitis has also been reported.
Mutation data reported. See also
ALCOHOLS. Flammable liquid. Moderately
explosive when exposed to flame.
ACGIH TLV: TwA PPm (sensitizer); Not effects, A Severe sktn and eye irritant.
SAFETY by voladty, The use of normal butyl alcohol is
liquid when exposed to heat Or flame* To the fingerndi and along the side of the
| [Hazardous Substances Data]
71-36-3(Hazardous Substances Data) | [IDLA]
1,400 ppm |
| Questions And Answer | Back Directory | [Characteristics and history of discovery]
1-Butanol is a type of alcohol with four carbon atoms being contained per molecule. Its molecular formula is CH3CH2CH2CH2OH with three isomers, namely iso-butanol, sec-butanol and tert-butanol. It is colorless liquid with alcohol odor.
It has the boiling point of being 117.7 ℃, the density (20 ℃) being ??0.8109g/cm3, the freezing point being-89.0 ℃, flash point being 36~38 ℃, self-ignition point being 689F and the refractive index being (n20D) 1.3993. At 20 ℃, its solubility in water is 7.7% (by weight) while the water solubility in 1-butanol was 20.1% (by weight). It is miscible with ethanol, ether and other kinds of organic solvents. It can be used as the solvents of a variety of paints and the raw material for producing the plasticizers, dibutyl phthalate. It can also be used for the manufacture of butyl acrylate, butyl acetate, and ethylene glycol butyl ether and also used as the extract of intermediates of organic synthesis and biochemical drugs and can also used in the manufacture of surfactants. Its steam can form explosive mixtures with air with the explosion limit being 3.7%~10.2% (volume fraction).
1-butanol was first discovered by C-A. Wurtz (French) from the fusel oil obtained from the fermentation process of alcohol in 1852. In 1913, the British Strange-Graham Companies have used corn as raw material for production of acetone through the fermentation process with butanol being the main byproduct. Later, due to the increasing demand for butanol, the fermentation production factory began to mainly synthesize n-butanol with acetone and ethanol being the major byproduct. During the Second World War, the German chemical company (Ruhr) began to apply propylene carboxyl method for the production of 1-butanol. With the rise of the oil industry in 1950s, the 1-butanol synthesis method had gotten rapid development with the propylene carboxyl method having the fastest speed.
| [Preparation of water saturated 1-butanol solution]
Add 21 mL of water and 100 mL of 1-butanol to separating funnel of 150 mL, shake for 3 min, stand for layering; and then remove the lower layer with the upper layer being water-saturated 1-butanol solution. (The density of water: 1 g/ml; 1-butanol density: 0.808~0.811 g/ml).
| [Content Analysis]
For the determination of 1-butanol and volatile impurities according to the general gas chromatography (GT-10), use the following conditions:
Column steel column, length: 1.8m; inner diameter: 6.4mm, the packing material should be 10% polyethylene glycol 400M (PEG 400M) with the carrier being 60/80 mesh diatomaceous soil carrier.
Carrier gas: Helium with a flow rate of 45ml/min. Detector: Flame ionization type.
Injector temperature 150 ℃, column temperature 90 0 ℃ detector 150 ℃.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
| [Toxicity]
ADI value is not specified (FAO/WHO, 1994).
GRAS (FEMA).
LD50: 790 mg/kg (rat, oral).
| [Uses]
1-Butanol is the most important in industries and the most extensively studied. 1-Butanol is a colorless liquid with a strong, mildly alcoholic odor. It is used in chemical derivatives and as a solvent for paints, waxes, brake fluid, and cleaners.
Butanol is the allowable food flavors documented in the "food additives health standards" of China. It is mainly used for the preparation of food flavors of bananas, butter, cheese and whiskey. For the candy, the usage amount should be 34mg/kg; for baked foods, it should be 32mg/kg; for soft drinks, it should be 12mg/kg; for cold drinks, it should be 7.0mg/kg; for the cream, it should be 4.0mg/kg; for alcohol, it should be 1.0mg/kg.
It is mainly used for the manufacture of the n-butyl plasticizers of phthalic acid, aliphatic dicarboxylic acid and phosphoric acid that are widely applied to various kinds of plastic and rubber products. It can also be used as the raw material of producing butyraldehyde, butyric acid, butyl-amine and butyl lactate in the field of organic synthesis. It can also be used as the extraction agent of oil, drugs (such as antibiotics, hormones and vitamins) and spices as well as the alkyd paint additives. It can be used as the solvent of organic dyes and printing ink and de-waxing agent.
| [Production method]
There are several methods for their preparation.
Fermentation
In the past, the production of butanol has also used potatoes, grain or sugar as raw material and through their hydrolysis fermentation. The resulting product from the fermentation broth contains a butanol content of 54.8%~58.5%, acetone content of 30.9%~33.7%, and the ethanol content of 7.8%-14.2%. With the development of petrochemical industry, fermentation method has been gradually phased out. The reaction equation is as follows: (C6H10O5) n [n (H2O)] → [strain] n-C6H12O6 [fermentation] → CH3COCH3 + C4H9OH + C2H5OH
The resulted fermentation broth was further fractionated to obtain acetone, ethanol and n-butanol separately.
Acetaldehyde method
Take acetaldehyde as raw material, add dilute alkali solution to give 2-hydroxybutyraldehyde at temperature below 20 ℃ with the reaction being stopped upon reaching 50%. Use alkali to neutralize the acid and recycle the unreacted acetaldehyde and extract the 2-hydroxybutyraldehyde. Then use acidic catalyst such as sulfuric acid and acetic acid for dehydration to obtain crotonaldehyde at 105~137 ℃, then use copper complex catalyst for hydrogenation at 160~240 ℃ to obtain the crude butyraldehyde and 1-butanol with distillation to obtain the products. CH3CH = CHCHO + H2 [catalyst] CH3CH2CH2CHO + CH3CH2CH2CH2OH
Its synthesis method including the following several ways:
Fermentation and Propylene carbonyl synthesis
Put propylene, carbon monoxide and hydrogen to the catalytic bed for reaction with catalyst being zeolite for absorbing cobalt salt or fatty acid cobalt with the reaction temperature being 130~160 ℃ and the reaction pressure being 20~25MPa. The reaction can generate n-butyraldehyde and iso-butyraldehyde with separation via distillation and further catalytic hydrogenation of the n-butyraldehyde to obtain the 1-butanol. CH3CH2CH2CHO + H2 → CH3CH2CH2CH2OH
You can alternatively use low pressure method with first-step method of propylene, carbon monoxide and water for synthesizing the butanol with the reaction temperature being 100~104 ℃ and pressure being 1.5MPa. It applies the mixture of iron pentacarbonyl, n-butyl pyrrolidine and water. However, the one-way conversion of the propylene is low with only 8% to 10%. Reaction equation: CH3CH = CH2 + 3CO + 2H2O → n-C4H9OH + 2CO2
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