| Identification | Back Directory | [Name]
ISORHYNCHOPHYLLINE | [CAS]
6859-01-4 | [Synonyms]
IsoRhy
SUCROSE(USP)(RG)
Isorhyncophylline
ISORHYNCHOPHYLLINE
7-Isorhyncophylline
7-Isorhynchophylline
Isorhynchophylline CRS
ISORHYNCHOPHYLLINE (P)
ISORHYNCHOPHYLLINE (RG)
Isorhynchophylline, 98%, from Uncaria rhynchophylla(Miq.)Miq. ex Havil.
(16E,20α)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
(7S,16E,20R)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
(aE,1'S,6'R,7'S,8'aS)-6'-Ethyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester
Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)- | [Molecular Formula]
C22H28N2O4 | [MDL Number]
MFCD01745920 | [MOL File]
6859-01-4.mol | [Molecular Weight]
384.47 |
| Chemical Properties | Back Directory | [Melting point ]
114℃ | [Boiling point ]
560.8±50.0 °C(Predicted) | [density ]
1.23 | [solubility ]
DMSO : 100 mg/mL (260.10 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
powder | [pka]
13.61±0.60(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Description]
This amorphous base has been isolated from Ourouparia rhyncophylla Mats. It
has [α]29Db + 8.3° and yields a crystalline perchlorate, m.p. 150°C (dec.). | [Uses]
Isorhynchophylline is an oxindole alkaloid which has been the main active ingredient of Uncaria rhynchophylla contributing to anti-depressant like behavior in subjects. | [Definition]
ChEBI: A natural product found in Uncaria macrophylla. | [target]
Potassium Channel | [References]
Kondo, Fukuda, Tomita., J. Pharm. Soc., Japan, 48, 54 (1928)
Kondo, Ikeda., ibid, 57,237 (1937) |
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