| Identification | Back Directory | [Name]
ISOGINKGETIN | [CAS]
548-19-6 | [Synonyms]
ISOGINKGETIN
ISOGINKGETIN(SH)
Isoginkgetin, >99%
4',4'''-Dimethylamentoflavone
ISOGINKGETIN(RG)(PLEASE CALL)
4',4'''-Dimethoxyamentoflavone
Isoginkgetin, 98%, from Ginkgo biloba L.
5,5'',7,7''-Tetrahydroxy-4',4'''-dimethoxy-3''',8-biflavone
3''',8-Biflavone, 5,5'',7,7''-tetrahydroxy-4',4'''-dimethoxy-
8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one
2-(4-Methoxyphenyl)-8-[6-methoxy-3-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)- | [Molecular Formula]
C32H22O10 | [MDL Number]
MFCD00597035 | [MOL File]
548-19-6.mol | [Molecular Weight]
566.51 |
| Chemical Properties | Back Directory | [Melting point ]
355℃ | [Boiling point ]
843.6±65.0 °C(Predicted) | [density ]
1.506 | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml | [form ]
powder | [pka]
6.16±0.40(Predicted) | [color ]
White-beige | [LogP]
5.240 (est) |
| Hazard Information | Back Directory | [Description]
Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing.1 Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; Item No. 14951) and LPS by approximately 87 and 90%, respectively.2 It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and the calcium ionophore A23187 (Item No. 11016) by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM.3 Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.4 | [Definition]
ChEBI: A biflavonoid resulting from the formal oxidative dimerisation between position 8 of one molecule of 5,7-dihydroxy-4'-methoxyflavone and the 3' position of another. Found in the leaves of Ginkgo biloba, it is a potent inhibitor of matrix metal
oproteinase 9 (MMP-9). | [General Description]
A cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax = 50 μM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 μM for 24 h). | [storage]
Store at 2-8°C |
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