| Identification | Back Directory | [Name]
NONACTIN | [CAS]
6833-84-7 | [Synonyms]
3584-a
a-5584
e-79-c
n-329-a
NONACTIN
ta-25-m-i
fh-3582-a
POLYNACTIN
WERRAMYCIN A
NONACTIN USP/EP/BP
AMMONIUM IONOPHORE
AMMONIUM IONOPHORE I
nonactinfromstreptomycessp.
NONACTIN, STREPTOMYCES GRISEUS
Ammonium ionophore, Nonactin
NONACTINE, STREPTOMYCES GRISEUS
NONACTINE, FROM STREPTOMYCES SP.
NONACTIN FROM STREPTOMYCES GRISEUS
NONACTIN FROM STREPTOMYCES TSUSIMAENSIS
WerraMycin, FH 3582A, NSC 52141, AKD 1A, KD 1A
Nonactin from Streptomyces griseus var griseus
Nonactin, Amonium Ionophore, Werramycin A, Polynactin
Nonactin (Mixture contains Monactin and Dinactin) (Technical Grade)
28))tetracontane-3,12,21,30-tetrone,2,5,11,14,20,23,29,32-octamethyl-2(1r
4,13,22,31,37,38,39,40-octaoxapentacyclo(32.2.1.1(sup7,10).1(sup16,19).1(sup
-(1r*,2r*,5r*,7r*,10s*,11s*,14s*,16s*,19r*,20r*,23r*,25r*,28s*,29s*,32s*,34s*)
Nonactin /
5342 Pfw 19 / A 4426 / Ammonium ionophore I
(1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)- | [EINECS(EC#)]
229-911-3 | [Molecular Formula]
C40H64O12 | [MDL Number]
MFCD00043039 | [MOL File]
6833-84-7.mol | [Molecular Weight]
736.93 |
| Chemical Properties | Back Directory | [Melting point ]
147-148° | [Boiling point ]
890.6±65.0 °C(Predicted) | [density ]
1.11-1.15 g/cm3 | [storage temp. ]
2-8°C
| [solubility ]
chloroform: soluble10mg/mL | [form ]
White to off-white crystalline solid. | [color ]
white to faint yellow | [Sensitive ]
Moisture Sensitive | [Merck ]
13,6709 | [BRN ]
76434 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| Hazard Information | Back Directory | [Description]
Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ .1 Upregulates levels of mitochondrial stress proteins HSP58 and GRP75.2 Nonactin abolishes mitochondrial membrane potential.3 | [Chemical Properties]
Light yellow powder | [Uses]
Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. | [Definition]
ChEBI: Nonactin is a macrotetrolide. | [Biological Activity]
Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic. | [storage]
Desiccate at -20°C | [Purification Methods]
This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.] | [References]
1) Garcia et al. (2003), Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occulded in EVA membrane; J. Pham. Biomed. Anal., 31 11
2) Mizzen et al. (1989), Identification, characterization and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein; J. Biol. Chem., 264 20664
3) Dudani et al. (1990), Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria; Cytobios, 63 95 |
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| Company Name: |
Lynnchem
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86-(0)29-85992781 17792393971 |
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http://www.lynnchem.com/ |
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