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ChemicalBook--->CAS DataBase List--->64744-50-9

64744-50-9

64744-50-9 Structure

64744-50-9 Structure
IdentificationMore
[Name]

Gabapentin-lactam
[CAS]

64744-50-9
[Synonyms]

2-AZA-SPIRO[4.5]DECAN-3-ONE
3,3'-PENTAMETHYLENE-4-BUTYROLACTAM
3,3-PENTAMETHYLENE-4-BUTYROLACTAM
3-AZASPIRO[4.5]DECAN-2-ONE
4,4-PENTAMETHYLENE-2-PYRROLIDINONE
Gabapentin-lactam
beta,beta-pentamethylen-gamma-butyrolactam
3,3-Pentamethylene glutarimide (CDI) or 2-Azaspiro{4,5} decan-3-one
3,3-PENTAMETHYLENE-4-BUTYROLACTAM(CDI) 98.0+%
3,3-Pentamethylene-4-butyrolactame2-Azaspiro[4.5]decan-3-one
forgabapentine
3-Azaspiro-[4,5]decan-3-one
Gabapentin Related Compound A
3,3-Pentamethylene-4-butyrolac
4,4-pentamethylene-2-pyrrolidone
3,3-Pentenylene-4-butyrolactam
3,3-Pentamethylene glutarimide (CDI)
3,3-Pentamethylene-4-butyrolactam(Gabalactam)(CDI)
3,3-Pentamethylene-4-Butyrolactam DI
1-(Aminomethyl)cyclohexane-1-acetic acid-lactam
[EINECS(EC#)]

451-630-1
[Molecular Formula]

C10H15NO3
[MDL Number]

MFCD00177938
[Molecular Weight]

197.23
[MOL File]

64744-50-9.mol
Chemical PropertiesBack Directory
[Appearance]

White Solid
[Melting point ]

84-89 °C(lit.)
[Boiling point ]

181 °C / 13mmHg
[density ]

1.05±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

Soluble in DMSO (up to 40 mg/ml)
[form ]

neat
[pka]

16.39±0.20(Predicted)
[color ]

White
[Usage]

Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
[InChIKey]

JAWPQJDOQPSNIQ-UHFFFAOYSA-N
[CAS DataBase Reference]

64744-50-9(CAS DataBase Reference)
Safety DataBack Directory
[Safety Statements ]

S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
[WGK Germany ]

3
[RTECS ]

CM0120000
[HazardClass ]

IRRITANT
[HS Code ]

29337900
Hazard InformationBack Directory
[Description]

Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4
[Chemical Properties]

Gabapentin-lactam is White Solid
[Uses]

Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels
[Uses]

Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.
[Definition]

ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound.
[General Description]

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
[References]

1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131 2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181 3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240 4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

64744-50-9(sigmaaldrich)
[TCI AMERICA]

4,4-Pentamethylene-2-pyrrolidone,>98.0%(GC)(64744-50-9)
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