| Identification | Back Directory | [Name]
ALLOMATRINE | [CAS]
641-39-4 | [Synonyms]
6β-Matrine
ALLOMATRINE
6-Allomatrine
Tetrahydroisosophoramine
Allomatrine
6-Allomatrine
4-(2-Biphenylyl)-1-(hydroxymethyl)-10-oxa-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
4-(2-Biphenylyl)-1-(hydroxymethyl)-10-oxa-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aS,13aR,13bR,13cR)- | [Molecular Formula]
C15H24N2O | [MOL File]
641-39-4.mol | [Molecular Weight]
248.36 |
| Chemical Properties | Back Directory | [Melting point ]
106-107 ºC | [Boiling point ]
396.7±31.0 °C(Predicted) | [density ]
1.16 | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
9.47±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors[1][2]. | [target]
Bcl-2/Bax | Caspase | Akt | ROS | NF-kB | CDK | [References]
[1] Long Pan, et al. Chemical Constituents of Alkaloids From the Bark of Sophora Japonica. Zhong Yao Cai. 2016 Sep;39(9):2027-9. PMID:30209906
[2] Seiichi Kobashi , et al. Antinociceptive Effects of 1-acyl-4-dialkylaminopiperidine and 1-alkyl-4-dialkylaminopiperidine in Mice: Structure-Activity Relation Study of Matrine-Type Alkaloids. Biol Pharm Bull. 2002 Aug;25(8):1030-4. DOI:10.1248/bpb.25.1030 |
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