| Identification | More | [Name]
3-Nitro-L-tyrosine | [CAS]
621-44-3 | [Synonyms]
3-NITRO-4-HYDROXY-PHENYLALANINE
3-NITRO-L-TYROSINE
3-NITRO-TYROSINE
H-3-NITRO-L-TYROSINE
H-3-NITRO-TYR-OH
H-4-HYDROXY-3-NITRO-PHE-OH
H-M-NITRO-TYR-OH
H-TYR(3-NO2)-OH
H-TYR(M-NO2)-OH
M-NITRO-L-TYROSINE
NITROTYROSINE
Tyr(3'-NO2)
3-NITRO-TYROSINEH-TYR(3-NO2)-OH
3-Nitro-L-tyrosine 99%
(2R)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid
L-Tyrosine, 3-nitro- | [EINECS(EC#)]
210-688-6 | [Molecular Formula]
C9H10N2O5 | [MDL Number]
MFCD00007123 | [Molecular Weight]
226.19 | [MOL File]
621-44-3.mol |
| Chemical Properties | Back Directory | [Appearance]
ochre-yellow to yellow-green powder | [Melting point ]
233-235 °C (dec.) (lit.) | [alpha ]
4 º (c=1, 1N HCl) | [Boiling point ]
367.79°C (rough estimate) | [density ]
1.4160 (rough estimate) | [refractive index ]
1.5373 (estimate) | [storage temp. ]
-15°C | [solubility ]
Aqueous Acid (Slightly), Water | [form ]
crystalline
| [pka]
2.17±0.20(Predicted) | [color ]
yellow to green
| [Water Solubility ]
insoluble | [BRN ]
2813157 | [CAS DataBase Reference]
621-44-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29225090 |
| Hazard Information | Back Directory | [Description]
Nitrotyrosine is formed by peroxynitrite-mediated nitration of protein tyrosine residues. Its presence on proteins can be used as a marker for peroxynitrite formation in vivo.1,2,3,4 Both free and protein-bound nitrotyrosine are commonly found in mammalian tissues and are increased in pathological conditions.2,5,6 The basal levels of free nitrotyrosine in human plasma is approximately 3 nM as determined by gas chromatography/mass spectrometry.7,8 | [Chemical Properties]
ochre-yellow to yellow-green powder | [Uses]
3-Nitro-L-tyrosine is used as an indicator of the formation of peroxynitrite by NO-dependent oxidative damage. | [Uses]
A marker for peroxynitrite. Oxidant and cytotoxic agent. | [Definition]
ChEBI: 3-nitro-L-tyrosine is a 3-nitrotyrosine comprising L-tyrosine having a nitro group at the 3-position on the phenyl ring. It is a L-tyrosine derivative, a non-proteinogenic L-alpha-amino acid and a 3-nitrotyrosine. It is an enantiomer of a 3-nitro-D-tyrosine. | [Biochem/physiol Actions]
Oxidant and cytotoxic agent. |
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