| Identification | More | [Name]
6-HYDROXYCOUMARIN | [CAS]
6093-68-1 | [Synonyms]
-HYDROXYCOUMARIN
6-hydroxy CourMarin
6-Hydroxycoumarin 97%
6-hydroxychromen-2-one
HYDROXYCOUMARIN, 6-(RG)
6-HYDROXY-2H-CHROMEN-2-ONE
6-Hydroxy-2H-chromen-2-one 97%
6-Hydroxy-2H-1-benzopyran-2-one
2H-1-Benzopyran-2-one, 6-hydroxy- | [Molecular Formula]
C9H6O3 | [MDL Number]
MFCD00630040 | [Molecular Weight]
162.14 | [MOL File]
6093-68-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
249-253 °C (lit.) | [Boiling point ]
248.82°C (rough estimate) | [density ]
1.2500 | [refractive index ]
1.5380 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Solid | [pka]
8.92±0.20(Predicted) | [color ]
White to yellow | [λmax]
349nm(EtOH)(lit.) | [LogP]
0.650 (est) | [CAS DataBase Reference]
6093-68-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29322010 |
| Hazard Information | Back Directory | [Description]
6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity. | [Occurrence]
6-Hydroxycoumarin is a natural product found in Grevillea robusta and Amburana cearensis with data available. | [Uses]
6-Hydroxycoumarin (cas# 6093-68-1) is a compound useful in organic synthesis. | [Preparation]
(1) synthesis of 6-aminocoumarins：In polar solvent, using 6- nitroscumarin as raw material, using hydrazine hydrate as hydrogen Source, is reducing catalyst using ferric chloride (FeCl36H2O), at ambient pressure reduces 6-nitroscumarin, prepare 6- aminocoumarins；
(2) synthesis of 6-Hydroxycoumarins：In sulfuric acid solution, one-step method is by 6-aminocoumarins after diazo-reaction Direct hydrolysis, prepares 6-Hydroxycoumarins in high yield.
The preparation method of 6 Hydroxycoumarins |
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