| Identification | More | [Name]
Glycine hydrochloride | [CAS]
6000-43-7 | [Synonyms]
AMINOACETIC ACID HYDROCHLORIDE
AMINOETHANOIC ACID HYDROCHLORIDE
GLYCINE HCL
GLYCINE-HCL BUFFER
GLYCINE HYDROCHLORIDE
GLYCOCOLL HYDROCHLORIDE
GLYCINE HYDROCHLORIDE SOLUTION
Aminoaceticacid.HCl=H-Gly-OH.HCl
Glycinehydrochloride,98%
h-gly-oh.hcl
Glycine solution hydrochloride
Glycocol hydrochloride | [EINECS(EC#)]
227-841-8 | [Molecular Formula]
C2H6ClNO2 | [MDL Number]
MFCD00012872 | [Molecular Weight]
111.53 | [MOL File]
6000-43-7.mol |
| Safety Data | Back Directory | [Risk Statements ]
22 | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 1789 8/PG 3
| [WGK Germany ]
2
| [RTECS ]
MC0560000
| [F ]
10 | [TSCA ]
Yes | [HS Code ]
29224999 |
| Hazard Information | Back Directory | [Chemical Properties]
white crystals or crystalline powder | [Uses]
Glycine hydrochloride is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors. | [Application]
Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.
Glycine hydrochloride has been used:
in the preparation of glycine-HCl buffer
to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
to regenerate the sensor to elute the bound C-reactive protein (CRP) | [Definition]
Glycine hydrochloride is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. | [Preparation]
Glycine hydrochloride can be prepared by the action of hydrochloric acid on hippuric acid,aminoacetonitrile,methyleneaminoacetonitrile, and on ethyl phthaliminoacetate. Aniline has been recommended for its conversion into free glycine. Glycine can also be prepared by the interaction of chloroacetic acid and ammonia; by the hydrolysis of methyleneaminoacetonitrile by successive treatments with barium hydroxide and sulfuric acid; and by the hydrolysis of aminoacetonitrile by means of barium hydroxide. A thorough study has been reported for its preparation in improved yields by the sulfuric acid hydrolysis of aminoacetonitrile, and in satisfactory yields from chloroacetic acid and ammonia. Other methods of preparation include the reduction of cyanoformic esters, a modified Curtius degradation of ethyl cyanoacetate, and the hydrolysis of the neck ligaments of cattle.
synthesis of Glycine hydrochloride | [Flammability and Explosibility]
Notclassified | [Biochem/physiol Actions]
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors. | [Purification Methods]
Crystallise the salt from absolute EtOH or 80% EtOH. Monoglycine hydrochloride has m 176-177o, and diglycine monohydrochloride has m 187o. [Frost J Am Chem Soc 64 1286 1942, Beilstein 4 III 1111, 4 IV 2353.] |
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