Identification | More | [Name]
L-DIHYDROOROTIC ACID | [CAS]
5988-19-2 | [Synonyms]
DIHYDRO-L-OROTIC ACID L-DIHYDROOROTIC ACID L-HYDROOROTIC ACID (S)-(+)-HYDROOROTIC ACID (S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid (4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid (S)-Dihydroorotate (S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid Adenosine-5'-diphosphoric acid Na2 Adenosine-5-triphosphoric acid Na2 Deoxyribonucein acid(fish sperm) DNTPS Guanosine-5-diphosphate disodiun Guanosine-5-monophosphate disodiun Guanosine-5'-triphosphate disodiun Inosine-5-triphosphate trisodium Ribonuclein acid,yeast t-Ribonuclein acid,yeast | [EINECS(EC#)]
624-952-7 | [Molecular Formula]
C5H6N2O4 | [MDL Number]
MFCD00085339 | [Molecular Weight]
158.11 | [MOL File]
5988-19-2.mol |
Chemical Properties | Back Directory | [Appearance]
White to off-white crystalline powder | [Melting point ]
254-255 °C (dec.)(lit.)
| [Boiling point ]
283.16°C (rough estimate) | [density ]
1.523 | [refractive index ]
1.5090 (estimate) | [storage temp. ]
Store at 0-5°C | [solubility ]
DMSO (Slightly), Water (Slightly, Heated, Sonicated) | [form ]
Powder | [pka]
2.82±0.20(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble in water (partly), and dimethyl formamide. | [InChIKey]
UFIVEPVSAGBUSI-REOHCLBHSA-N | [CAS DataBase Reference]
5988-19-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Orotic acid, dihydro-, l-(5988-19-2) |
Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . | [WGK Germany ]
3
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Hazard Information | Back Directory | [Chemical Properties]
White to off-white crystalline powder | [Uses]
L-Dihydroorotic acid a metabolite. | [Definition]
ChEBI:(S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid. | [Biochem/physiol Actions]
L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors. | [storage]
Store at 2-8°C |
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