| Identification | More | [Name]
PHYSOSTIGMINE SALICYLATE | [CAS]
57-64-7 | [Synonyms]
ESERINE MONOSALICYLATE
ESERINE SALICYLATE
ESERINE SALICYLATE SALT
PHYSOSTIGMINE SALICYLATE
PHYSOSTIGMINE SALICYLATE SALT
2-hydroxy-,compd.with(3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-benzoicaci
ar-44
physostigmine,[salicylate(1:1)]
physostigmine,salicylate(1:1)
physostolsalicylate
salicylicacid,compd.withphysostigmine(1:1)
tl-1380
trimethylpyrrolo[2,3-b]indol-5-ylmethylcarbamate(1:1)
ESERINE SALICYLATE 99.9%
Physostigmine monosalicylate
Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo2,3-bindol-5-yl methylcarbamate (1:1)
PHYSOSTIGMINESALICYLATE,USP
ESERINE SALICYLATE(RG)
Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) (9CI)
Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) | [EINECS(EC#)]
200-343-8 | [Molecular Formula]
C22H27N3O5 | [MDL Number]
MFCD00135659 | [Molecular Weight]
413.47 | [MOL File]
57-64-7.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
181-183 °C | [storage temp. ]
-20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml | [form ]
neat | [pka]
pKa 1.96/8.08(H2O,t =15) (Uncertain) | [color ]
White to yellow | [biological source]
synthetic | [optical activity]
[α]20/D -77±2°, c =1% in ethanol | [Usage]
Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet | [Merck ]
7384 | [BRN ]
3900576 | [InChIKey]
HZOTZTANVBDFOF-DPKVYHSMNA-N | [SMILES]
C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r| | [CAS DataBase Reference]
57-64-7(CAS DataBase Reference) | [EPA Substance Registry System]
Physostigmine salicylate (57-64-7) |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
R26/28:Very Toxic by inhalation and if swallowed . | [Safety Statements ]
S25:Avoid contact with eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1544 6.1/PG 1
| [WGK Germany ]
3
| [RTECS ]
TJ2450000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
2939800000 | [Safety Profile]
Poison by ingestion,
subcutaneous, intramuscular, intravenous,
and intraperitoneal routes. Human systemic
effects: arrhythmias, nausea or vomiting.
Experimental reproductive effects. When
heated to decomposition it emits toxic
fumes of NOx See also
PHYSOSTIGMINE. | [Toxicity]
LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch) |
| Hazard Information | Back Directory | [General Description]
Crystal form that turns red on exposure to heat or light. | [Reactivity Profile]
Behaves as a weak acid in solution. | [Health Hazard]
This compound is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor. | [Fire Hazard]
When heated to decomposition, PHYSOSTIGMINE, [SALICYLATE (1:1)] emits toxic fumes of nitrogen oxides. | [Chemical Properties]
solid | [Uses]
cholinergic, anticholinesterase, miotic | [Uses]
Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet | [Definition]
ChEBI: Physostigmine salicylate is an azaheterocycle salicylate salt and a member of salicylates. It contains a physostigmine. | [Brand name]
Antilirium (Forest); Isopto Eserine (Alcon). | [Biological Activity]
Acetylcholinesterase inhibitor th at crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase th at degrades slowly. | [storage]
-20°C |
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