| Identification | More | [Name]
Phenobarbital sodium | [CAS]
57-30-7 | [Synonyms]
5-ethyl-5-phenyl-2,4,6-(1h,3h,5h)pyrimidinetrione monosodium salt
5-ETHYL-5-PHENYL-2,4,6-TRIOXOHEXAHYDROPYRIMIDINE SODIUM SALT
5-ETHYL-5-PHENYLBARBITURIC ACID SODIUM SALT
LUMINAL SODIUM
LUMINAL SODIUM SALT
PHENOBARBITAL SODIUM
PHENOBARBITAL SODIUM SALT
PHENOBARBITONE SODIUM
SODIUM 5-ETHYL-5-PHENYLBARBITURATE
4,6(1h,3h,5h)-pyrimidinetrione,5-ethyl-5-phenyl-monosodiumsalt
5-ethyl-5-phenyl-barbituricacisodiumsalt
fenobarbitalnatrium
gardenalsodium
phenobalsodium
phenobarbitalelixir
phenobarbitalna
phenobarbitonesodiumsalt
phenyl-aethyl-barbitursaeurenatrium
phenylethylbarbituricacid,sodiumsalt
sodiumluminal | [EINECS(EC#)]
200-322-3 | [Molecular Formula]
C12H10N2Na2O3 | [MDL Number]
MFCD00036211 | [Molecular Weight]
276.2 | [MOL File]
57-30-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R25:Toxic if swallowed.
R40:Limited evidence of a carcinogenic effect.
R43:May cause sensitization by skin contact. | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
-
| [RTECS ]
CQ7000000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Safety Profile]
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intravenous, intraperitoneal, intraduodenal, and subcutaneous routes. Human systemic effects by ingestion: nausea or vomiting and coma. Experimental reproductive effects. Mutation data reported. Used to treat epilepsy, as a hypnotic and sedative. When heated to decomposition it emits toxic fumes of NOx and NazO. See also BARBITURATES | [Toxicity]
LD50 orally in rats: 660 mg/kg (Schaffarzick, Brown) |
| Hazard Information | Back Directory | [General Description]
Odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic. | [Reactivity Profile]
SODIUM PHENOBARBITAL(57-30-7) can react with strong oxidizing agents. Incompatible with ammonium salts and chloral hydrate. Also incompatible with acids and acidic substances . | [Air & Water Reactions]
Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble. Aqueous solutions are unstable, but may be kept at or below 50°F for a few days. | [Fire Hazard]
Flash point data for this chemical are not available; however, SODIUM PHENOBARBITAL is probably combustible. | [Chemical Properties]
Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y7 (2.2.2, Method II). | [Uses]
Anticonvulsant; sedative-hypnotic. | [Definition]
ChEBI: A barbiturate that is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups). | [Brand name]
Luminal Sodium (Sterling Winthrop). | [Biochem/physiol Actions]
Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation. It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA?receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus. |
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