| Identification | More | [Name]
1-Nitropyrene | [CAS]
5522-43-0 | [Synonyms]
1-NITROPYRENE
LABOTEST-BB LT00894548
3-Nitropyrene
Pyrene, 1-nitro-
23264, 1-Nitropyrene (purity)
NITROPYRENE
1-NITROPYRENE (100UG/ML IN TOLUENE)
1-NITROPYRENE 98+%
Nitropyrene, Mono-, Di-, Tri-Tetra, isomers | [EINECS(EC#)]
226-868-2 | [Molecular Formula]
C16H9NO2 | [MDL Number]
MFCD00004138 | [Molecular Weight]
247.25 | [MOL File]
5522-43-0.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to orange-brown or khaki powder | [Melting point ]
153-155 °C (lit.) | [Boiling point ]
390.29°C (rough estimate) | [density ]
1.1699 (rough estimate) | [refractive index ]
1.5300 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Sparingly, Heated), Ethyl Acetate (Slightly, Heated) | [form ]
neat | [color ]
Yellow needles from MeCN | [BRN ]
1882811 | [InChIKey]
ALRLPDGCPYIVHP-UHFFFAOYSA-N | [CAS DataBase Reference]
5522-43-0(CAS DataBase Reference) | [IARC]
2A (Vol. Sup 7, 46, 105) 2014 | [NIST Chemistry Reference]
1-Nitropyrene(5522-43-0) | [EPA Substance Registry System]
5522-43-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R40:Limited evidence of a carcinogenic effect.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3
| [RTECS ]
UR2480000
| [TSCA ]
T | [HazardClass ]
IRRITANT | [HS Code ]
29420000 | [Hazardous Substances Data]
5522-43-0(Hazardous Substances Data) | [Toxicity]
mic-sat 2500 ng/plate GDIKAN 29,278,1981 | [Toxicity]
mmo-esc 3 mg/plate MUREAV 142,163,85 |
| Hazard Information | Back Directory | [General Description]
Yellow needles or prisms (from ethanol). | [Reactivity Profile]
1-NITROPYRENE(5522-43-0) may be sensitive to prolonged exposure to light. Reacts with ethanolic potassium hydroxide. Also reacts with zinc powder and ethanol with catalytic amounts of ammonium chloride or ammonia . | [Air & Water Reactions]
Insoluble in water. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: When heated to decomposition this chemical emits toxic fumes of NOx. | [Fire Hazard]
Flash point data for this chemical are not available; however, 1-NITROPYRENE is probably combustible. | [Description]
1-Nitropyrene (1-NP) is a nitro-polycyclic aromatic hydrocarbon
(PAH) and a byproduct of incomplete combustion
product from stationary combustion sources and in vehicle
exhaust fumes. | [Chemical Properties]
yellow to orange-brown or khaki powder | [Uses]
1-Nitropyrene has been reported to be a chemical photosensitizer, and one non-U.S. company was reported to have used it as an intermediate in the production of 1-azidopyrene, which is used in photosensitive printing. 1-Nitropyrene is available for research purposes at a purity of 97% or of greater than 99.5% with no more than 0.1% total dinitropyrenes and pyrene. It also is available as a reference material at a purity of 99.68% (IARC 1989). | [Uses]
1-Nitropyrene is the most abundant nitropolycylcic aromatic hydrocarbon found in exhaust from diesel engines with potent carcinogenic and mutagenic properties. | [Uses]
1-NP has been reported to use as a chemical photosensitizer in
photocopy toners. It is available for research purposes as
a reference material with different purities. | [Application]
1-Nitropyrene has been reported to use as a chemical photosensitizer in photocopy toners. It is available for research purposes as a reference material with different purities.
? | [Definition]
ChEBI: A nitroarene that is pyrene substituted at the 1-position by a nitro group. A by-product of combustion, it is the predominant nitrated polycyclic aromatic hydrocarbon emitted in a diesel engine. | [Preparation]
The synthesis of 1-nitropyrene by heating pyrene with nitric acid in acetic acid at 50 °C (Boit, 1965). 1-Nitropyrene was also produced in a mixture with dinitropyrenes following the addition of potassium nitrite to pyrene in diethyl ether (Prager & Jacobson, 1922). | [Synthesis Reference(s)]
Journal of the American Chemical Society, 93, p. 1811, 1971 DOI: 10.1021/ja00736a057 | [Biochem/physiol Actions]
Potent mutagen, carcinogen, environmental pollutant. | [Safety Profile]
Confirmed carcinogen withexperimental carcinogenic, neoplastigenic, andtumorigenic data. Human mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx. | [Safety Profile]
Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx. | [Carcinogenicity]
1-Nitropyrene is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals. | [Environmental Fate]
1-NP creates yellow needles in ethanol, and it has a melting
point of 155 ℃. It is partially insoluble in water (0.02 mg l-1,
25 ℃); very soluble in diethyl ether; and soluble in acetone,
ethanol, benzene, toluene, and tetrahydrofluorenone.
1-NP upon an estimated Koc value (soil adsorption coefficient
normalized to the content of organic carbon) of 13 500 is
immobile in soil and adsorb to sediment and solids from
water. According to Henry’s law constant of 2.5× 10-8 atmcum
mol1 and vapor pressure (8.3 ×10-8 mmHg at 25℃)
volatilization from moist soil surfaces and water is not an
important fate process. It is expected to exist solely in the
particulate phase in the ambient atmosphere. Adsorptions to
the particulate phase cause occurring photolysis in lower rate
and decompose by wet and dry deposition. An estimated bioconcentration
factor of 4100 suggests that its concentration in
aquatic organisms is very high. | [Toxicity evaluation]
1-NP can generate aryl nitrenium ions by nitroreduction or
K-region nitropyrene epoxides by ring oxidation. This chemical
can form DNA adducts. Both nitroreduction and the hydrolysis
of glucuronides are essential in generating mutagenic metabolites.
Another mechanism of toxicity is superoxide radical
generation. The activation of 1-NP to a bacterial mutagen has
been attributed to nitroreduction. However, enzymes of
mammalian and microbial systems can reduce it to products
such as 2-aminofluorene and 4-aminobiphenyl that react with
nucleic acid and can be further metabolized by O-acetylation to
yield products that can react with C-8 of guanine. |
|
|