| Identification | More | [Name]
Atropine sulfate | [CAS]
55-48-1 | [Synonyms]
(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenyl-propanoate sulphate
alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate monohydrate
ATROPINE SULFATE
ATROPINE SULFATE, ATROPA BELLADONNA (LINNAEUS)
ATROPINE SULPHATE
1-alpha-h,5-alpha-h-tropan-3-alpha-ol(+-)-tropate(ester),sulfate(2:1)sal
atropette
atropine,sulfate(2:1)
atropiniumsulfate
atropinsal
atropinsiran
atropinsulfat
atropinysiarczan
atropisal
corbella
davurtrop
dl-tropanyl2-hydroxy-1-phenylpropionatesulfate
eyesule
ichtho-bellol
lio-atropin | [EINECS(EC#)]
200-235-0 | [Molecular Formula]
C17H25NO7S | [MDL Number]
MFCD00077268 | [Molecular Weight]
387.45 | [MOL File]
55-48-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
R26/28:Very Toxic by inhalation and if swallowed . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1544 6.1/PG 2
| [WGK Germany ]
2
| [F ]
3-8-10 | [Safety Profile]
Poison by
subcutaneous, intravenous, and
intraperitoneal routes. Moderately toxic by
ingestion. Human (child) pulmonary system
effects by ingestion. Human systemic
effects: decreased body temperature, cardiac
arrhythmias. An experimental teratogen.
Other experimental reproductive effects. See
also ATROPINE. When heated to
decomposition it emits very toxic fumes of
NO,xand SOx. | [Toxicity]
LD50 oral in rat: 600mg/kg |
| Hazard Information | Back Directory | [Uses]
anticholinergic agent | [Uses]
cholinergic receptor antagonist | [Brand name]
Atrophate [Veterinary]
(Schering-Plough Animal Health); Atropisol
(Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon). | [General Description]
Atropine sulfate (Atropisol)is prepared by neutralizing atropine in acetone or ethersolution with an alcoholic solution of sulfuric acid, withcare used to prevent hydrolysis. The salt occurs as colorlesscrystals or as a white, crystalline powder. It is efflorescentin dry air and should be protected from light to preventdecomposition.
Atropine sulfate is freely soluble in water (1:0.5), in alcohol(1:5, 1:2.5 at boiling point), and in glycerin (1:2.5).Aqueous solutions are not very stable, although solutionsmay be sterilized at 120°C (15 lb pressure) in an autoclave if the pH is kept below 6. Sterilization probably is besteffected by the use of aseptic techniques and a bacteriologicalfilter. It has been suggested that no more than a 30-daysupply of an aqueous solution should be made and that forsmall quantities the best procedure is to use hypodermictablets and sterile distilled water. Kondritzer andZvirblis have studied the kinetics of alkaline and protoncatalyzedhydrolyses of atropine in aqueous solution. Theregion of maximal stability lies between pH 3 and approximately5. They have also proposed an equation to predictthe half-life of atropine undergoing hydrolysis at constantpH and temperature. | [Clinical Use]
Atropine may be used to treat some types of arrhythmias. Itincreases the heart rate by blocking the effects of ACh on thevagus. In this context, it is used to treat certain reversible bradyarrhythmiasthat may accompany acute myocardial infarction.It is also used as an adjunct to anesthesia to protect againstbradycardia, hypotension, and even cardiac arrest induced bythe skeletal muscle relaxant succinylcholine chloride.
Another use for atropine sulfate emerged following thedevelopment of the organophosphates, which are potent inhibitorsof AChE. Atropine is a specific antidote to preventthe muscarinic effects of ACh accumulation, such as vomiting,abdominal cramps, diarrhea, salivation, sweating, bronchoconstriction,and excessive bronchial secretions. It isused intravenously but does not protect against respiratoryfailure caused by depression of the respiratory center andthe muscles of respiration. | [Veterinary Drugs and Treatments]
The principal veterinary indications for systemic atropine include:
!!Preanesthetic to prevent or reduce secretions of the respiratory
tract
!!Treat sinus bradycardia, sinoatrial arrest, and incomplete AV
block
!!Differentiate vagally-mediated bradycardia for other causes
!!As an antidote for overdoses of cholinergic agents (e.g., physostigmine,
etc.)
!!As an antidote for organophosphate, carbamate, muscarinic
mushroom, blue-green algae intoxication
!!Hypersialism
!!Treatment of bronchoconstrictive disease |
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