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ChemicalBook--->CAS DataBase List--->54662-30-5

54662-30-5

54662-30-5 Structure

54662-30-5 Structure
IdentificationBack Directory
[Name]

12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE
[CAS]

54662-30-5
[Synonyms]

12-DPPAA
3-acetate9a-phenylacetate
12-deoxyphorbolphenylacetate-20-acetate
12-Deoxyphorbol 13-phenylacate 20-acetate
12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE
(1aR)-3-(Acetyloxymethyl)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-1,1,6,8α-tetramethyl-9aα-[(phenylacetyl)oxy]-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
Benzeneacetic acid ,(1ar,1bs,4ar,7as,7br,8R,9as)-3-((acetyloxy)methyl)-1,1A,1B,4,4A,5,7A,7B,8,9-decahydro-4A,7B-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-E)azulen-9A-yl ester
5H-Cyclopropa(3,4)benz(1,2-E)azulen-5-one, 1,1A-alpha,1B-beta,4,4A,7A-alpha,7B,8,9,9A-decahydro-4A-beta,7B-alpha,9A-alpha-trihydroxy-3-(hydroxymethyl)-1,1,6,8-alpha-tetramethyl-, 3-acetate 9A-phenylacetate
[Molecular Formula]

C30H36O7
[MDL Number]

MFCD01741294
[MOL File]

54662-30-5.mol
[Molecular Weight]

508.6
Chemical PropertiesBack Directory
[Boiling point ]

556.46°C (rough estimate)
[density ]

1.0979 (rough estimate)
[refractive index ]

1.6810 (estimate)
[storage temp. ]

-20°C
[form ]

oil
[color ]

colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS06
[Signal word ]

Danger
[Hazard statements ]

H300+H310+H330-H315-H319-H335
[Precautionary statements ]

P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338
[Hazard Codes ]

T+
[Risk Statements ]

26/27/28-36/37/38
[Safety Statements ]

26-27-36/37/39-45
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

dPPA/phorbol ester 12-deoxyphorbol 13-phenylacetate 20-acetate (DOPPA) may be used as a potent activator of PKC-β:
  • to tre at transfected HT-22 cells to promote phosphorylation of p66Shc
  • to tre at HT-22 and B12 cells to study its effects on cell viability
  • to tre at neurons and measure primary cortical neurons using the 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay

[Biological Activity]

dPPA is a phorbol ester th at selectively activates the β isotype of PKC. It is approximately 100-fold more potent for PKC-β than the αγ or δ isotypes. PKC family members each have specific functionsbut PKC-β and δ appear to share similar expression profilesand both are involved in regulating apoptosis and B cell activationthus dPPA is a useful tool in determining PKCβ specific signaling events.
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