| Identification | Back Directory | [Name]
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE | [CAS]
63597-44-4 | [Synonyms]
4α-pma
4α-TPA
alpha-TPA
4ALPHA-PMA
4ALPHA-TPA
4-alpha-PMA, 4-alpha-TPA
4α-Phorbol 12-myristate 13-acetate
4a-Phorbol 12-Myristate 13-Acetate
4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE
4A-PHORBOL 12-MYRISTATE 13-ACETATE, 99+%
4ALPHA-12-O-TETRADECANOYLPHORBOL 13-ACETATE
4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE
4-alpha-Phorbol 12-Myristate 13-Acetate >99%
4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL
4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate
(1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate
Tetradecanoic acid,(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester | [Molecular Formula]
C36H56O8 | [MDL Number]
MFCD00153860 | [MOL File]
63597-44-4.mol | [Molecular Weight]
616.83 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: ~2 μM Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media. | [form ]
solid | [color ]
white | [Water Solubility ]
H2O: ~2μM
DMSO: soluble
ethanol: soluble | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes. | [Biochem/physiol Actions]
Negative control for phorbol ester activation of protein kinase C. |
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