| Identification | Back Directory | [Name]
ETOFYLLINE CLOFIBRATE | [CAS]
54504-70-0 | [Synonyms]
duolip
ml1024
Theofibrate
etofyllinclofibrat
etofyllinclofibrate
ETOFYLLINE CLOFIBRATE
Etofylline cIofibrate
ETOFYLLINE CLOFIBRATE USP/EP/BP
yl-2,6-dioxo-7h-purin-7-yl)ethylester
1-(7-theophyllinyl)-2-ethyl(2-(p-chlorophenoxy)isobutyrate)
1-(theophyllin-7-yl)-aethyl-22-(p-chlorphenoxy)-2-methylpropionat
1-(theophyllin-7-yl)-ethyl-22-(p-chlorophenoxy)-2-methylpropionate
propionicacid,2-(4-chlorophenoxy)-2-methyl-,2-(1,2,3,6-tetrahydro-1,3-dimeth
2-(1,3-dimethyl-2,6-dioxopurin-7-yl)ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
2-(4-Chlorophenoxy)-2-methylpropionic acid 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester
2-(4-Chlorophenoxy)-2-methylpropionic acid [2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl] ester
Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester | [EINECS(EC#)]
259-191-6 | [Molecular Formula]
C19H21ClN4O5 | [MDL Number]
MFCD01695637 | [MOL File]
54504-70-0.mol | [Molecular Weight]
420.85 |
| Chemical Properties | Back Directory | [Melting point ]
133-135° | [Boiling point ]
615.8±65.0 °C(Predicted) | [density ]
1.3758 (rough estimate) | [refractive index ]
1.6500 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 52 mg/mL (123.56 mM) | [form ]
Solid | [pka]
0.17±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Originator]
Duolip,Merckle,W. Germany,1981 | [Uses]
Duolip (L. Merckle, Germany). | [Definition]
ChEBI: Etofylline clofibrate is an oxopurine. | [Manufacturing Process]
107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol)
7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They
were heated together for 15 hours in a water separator following the addition
of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute
sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated
in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55%
yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The
compound had a melting point of 131°C to 132°C. | [Therapeutic Function]
Antihyperlipidemic | [storage]
Store at -20°C |
|
|