| Identification | More | [Name]
HIPPURIC ACID SODIUM SALT | [CAS]
532-94-5 | [Synonyms]
BENZOYLAMINOACETIC ACID SODIUM SALT
BENZOYLAMINOACETIC SODIUM SALT
HIPPURIC ACID SODIUM SALT
N-BENZOYLGLYCINE SODIUM SALT
SODIUM HIPPURATE
Glycine,N-benzoyl-,monosodiumsalt
hippuricacid,monosodiumsalt
n-benzoyl-glycinmonosodiumsalt
Sodium hippurate hydrate
Synonym Benzoylaminoacetic acid sodium salt
Hippuric acid sodium
HIPPURIC ACID SODIUM SIGMAULTRA
SodiumHippurate98%
Sodium Hippurate 98%
Sodiumhippurate,96%
CYCLO-PRO-HIS-OH
Benzoylaminoacetic acid sodium salt, Hippuric acid hydrate sodium salt, N-Benzoylglycine sodium salt
2-(Benzoylamino)acetic acid sodium salt | [EINECS(EC#)]
208-548-4 | [Molecular Formula]
C9H8NNaO3 | [MDL Number]
MFCD00002693 | [Molecular Weight]
201.15 | [MOL File]
532-94-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36/37:Wear suitable protective clothing and gloves .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S22:Do not breathe dust . | [WGK Germany ]
3
| [RTECS ]
MR8170000
| [TSCA ]
Yes | [HS Code ]
2924.29.9500 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder | [Uses]
Hippuric Acid Sodium Salt can be used for agrobacterium-mediated rice genetic transformation method. | [Biochem/physiol Actions]
Hippuric acid is a low molecular weight phenolic carboxylic acid urinary metabolite that may be a useful urinary biomarker for certain cancers such as gastric cancer and oxidative stress. | [in vivo]
Sodium hippurate, 98% (Hippuric acid, 100 mg/kg; i.p.; five times per week; 10 weeks) promotes renal fibrosis and dysfunction in 5/6 nephrectomized rats[4].
Sodium hippurate, 98% (Hippuric acid, 10 mg/kg; p.o.; daily; 4 weeks) alleviates hyperuricemia in mice by promoting intestinal urate excretion via enhancing ABCG2-mediated transport[5].
Sodium hippurate, 98% (Hippuric acid, 50-150 mg/kg; p.o.; once daily; 7 days) alleviates DSS-induced colitis in male C57BL/6J mice, as shown by reduced clinical activity, improved intestinal barrier integrity, and modulated gut microbiota[6].
| Animal Model: | Male Sprague Dawley rats (7-week-old, weight not specified); 5/6 nephrectomy model[4] | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal injection, five times per week, for 10 weeks | | Result: | Significantly increased levels of serum creatinine (SCr), blood urea nitrogen (BUN), and HA.
Showed increased tubulointerstitial fibrosis and glomerulosclerosis, with larger COL1A1-, VIM-, and ACTA2-positive areas.
Revealed lower NRF2 levels.
Decreased activities of SOD, CAT, and GSH- Px.
Increased MDA levels in the kidneys, indicating redox imbalance.
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| [IC 50]
MMP9; Microbial Metabolite; Human Endogenous Metabolite |
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