| Identification | More | [Name]
Tyramine | [CAS]
51-67-2 | [Synonyms]
2-(4-HYDROXYPHENYL)ETHYLAMINE
2-(P-HYDROXYPHENYL)ETHYLAMINE
4-(2-AMINOETHYL)PHENOL
4-HYDROXYPHENETHYLAMINE
4-HYDROXYPHENYLETHYLAMINE
AKOS NCG-0021
AURORA KA-7835
L-TYRAMINE
P-(2-AMINOETHYL)PHENOL
PHENOL, 4-(2-AMINOETHYL)-
RARECHEM AL BW 0088
TYRAMINE
TYROSAMINE
4-(2-aminoethyl)-pheno
4-(2-Aminoethyl)-phenol (thyramin)
4-hydroxy-benzeneethanamin
4-Hydroxy-beta-phenylethylamine
alpha-(4-Hydroxyphenyl)-beta-aminoethane
Benzeneethanamine, 4-hydroxy-
beta-(4-Hydroxyphenyl)ethylamine | [EINECS(EC#)]
200-115-8 | [Molecular Formula]
C8H11NO | [MDL Number]
MFCD00008193 | [Molecular Weight]
137.18 | [MOL File]
51-67-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light beige solid | [Melting point ]
160-162 °C(lit.)
| [Boiling point ]
175-181 °C8 mm Hg(lit.)
| [density ]
1.0630 (rough estimate) | [FEMA ]
4215 | [refractive index ]
1.5849 (estimate) | [Fp ]
165°C | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
9.74(at 25℃) | [color ]
Clear yellow to orange to slightly brown, may darken on storage | [Odor]
at 100.00 %. mild meaty dirty cooked phenolic rubbery | [Stability:]
Stable. Incompatible with strong acids, strong oxidizing agents. | [Odor Type]
meaty | [Water Solubility ]
1g/95mL (15 ºC) | [JECFA Number]
1590 | [Merck ]
9835 | [BRN ]
1099914 | [LogP]
1.38 | [Uses]
Clinical studies indicate that tyramine has skin-lightening capacities. | [CAS DataBase Reference]
51-67-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Phenol, 4-(2-aminoethyl)-(51-67-2) | [EPA Substance Registry System]
51-67-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
SJ5950000
| [F ]
10-23 | [HS Code ]
29222900 | [Hazardous Substances Data]
51-67-2(Hazardous Substances Data) | [Toxicity]
LD50 intracervical in mouse: 30mg/kg |
| Hazard Information | Back Directory | [Description]
A decarboxylation product of tyrosine found in various fermentation products, including cheeses and some wines.
It causes sympathomimetic effects by acting as an indirect agonist, causing the release of endogenous catecholamines.
Because it is metabolized principally by monoamine oxidase,
patients taking monoamine oxidase inhibitors may have a
hypertensive crisis if they ingest foods containing significant
amounts of tyramine. | [Chemical Properties]
Colorless to yellow solid; sweet meaty aroma. | [Chemical Properties]
white to light beige solid | [Occurrence]
Reported found in sauerkraut and soy sauce. | [Definition]
ChEBI: A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine. | [Aroma threshold values]
Medium strength odor, meaty type; recommend smelling in a 5.00% solution or less. | [Taste threshold values]
Mild, sweet, vegetative phenolic taste at 100 ppm in water. | [Synthesis]
Tyramine, 4-(2-aminoethyl)phenol (11.2.1), can be synthesized in various
ways, in particular by the decarboxylation of tyrosine [46¨C48]. It is also isolated from the
tissues of livestock.
| [Purification Methods]
Crystallise tyramine from *benzene or EtOH. [Beilstein 13 IV 1788.] |
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