| Identification | Back Directory | [Name]
songorine | [CAS]
509-24-0 | [Synonyms]
Songorin
Zongorine
Xuan-Wu 2
Napellonin
Napellonine
product/155133
ShiMoburo base I
Songorine,BullatineG
Bullatine G
Songorine
(20R)-21-Ethyl-1α,15β-dihydroxy-4-methyl-16-methylene-7α,20-cycloveatchan-12-one
(3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-Ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one
12,3,6a-Ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one, 1-ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-, (3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)- | [EINECS(EC#)]
200-158-5 | [Molecular Formula]
C22H31NO3 | [MDL Number]
MFCD04037233 | [MOL File]
509-24-0.mol | [Molecular Weight]
357.49 |
| Chemical Properties | Back Directory | [Melting point ]
201-203℃ | [alpha ]
D20 -135.4° | [Boiling point ]
535.8±50.0 °C(Predicted) | [density ]
1.29 | [solubility ]
DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 5 mg/ml; Ethanol: slightly soluble | [form ]
A solid | [pka]
14.20±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Songorine is an extract from the Aconitum flavum root and may act as an inhibitor of JNK and p53 enhancing stimulation of fibroblast colony/cluster formation and proliferative activity of mesosomal precursors. | [in vivo]
Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorine?inhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax[1].
Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD50 and ED50 values of 142 mg and 7.3mg, respectively[2]. |
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