| Identification | More | [Name]
1-BENZOYL-3-PHENYL-2-THIOUREA | [CAS]
4921-82-8 | [Synonyms]
usafk-1473
phenylbenzoylthiourea
1-Benzoyl-3-phenylthiourea
N-Benzoyl-N'-phenylthiourea
N-Phenyl-N'-benzoylthiourea
1-Benzoyl-3-phenyl(thiourea)
1-benzoyl-3-phenyl-2-thio-ure
1-BENZOYL-3-PHENYL-2-THIOUREA
n-phenylthiocarbamoyl-benzamid
N-(Phenylthiocarbamoyl)benzamide
N-[(PHENYLAMINO)THIOXOMETHYL]-BENZAMIDE
Benzamide, N-[(phenylamino)thioxomethyl]-
N-[anilino(sulfanylidene)methyl]benzamide | [Molecular Formula]
C14H12N2OS | [MDL Number]
MFCD00022118 | [Molecular Weight]
256.32 | [MOL File]
4921-82-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
159 °C | [density ]
1.290±0.06 g/cm3(Predicted) | [storage temp. ]
-20° | [solubility ]
Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 8 mg/ml). | [form ]
solid | [pka]
9.49±0.70(Predicted) | [color ]
Off-white | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | [CAS DataBase Reference]
4921-82-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
TM-2-51 (4921-82-8) is a highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. TM-2-51 rescues the activity of catalytically compromised HDAC8 mutants?in vitro.2 | [References]
1) Singh?et al. (2011), Histone deacetylase activators: N-acetylthioureas as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate; Bioorg. Med. Chem. Lett.,?21?5920
2) Decross?et al. (2014), Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders; ACS Chem. Biol.,?9?2157
3) Singh?et al. (2015),?Mechanism of N-acylthiourea Mediated Activation of Human Histone Deacetylase 8 (HDAC8) at Molecular and Cellular Levels; J. Biol. Chem.,?290?6607 |
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