| Identification | More | [Name]
MORIN | [CAS]
480-16-0 | [Synonyms]
2',3,4',5,7-PENTAHYDROXYFLAVONE
3,5,7,2',4'-PENTAHYDROXYFLAVONE
CI 75660
CI NO 75660
FUSTIC
MORIN
TIMTEC-BB SBB008853
2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4h-1-benzopyran-4-on
2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-Benzopyran-4-one
2’,3,4’,5,7-pentahydroxy-flavon
2’,4’,3,5,7-pentahydroxyflavone
2’-hydroxypelargidenolon1522
2-2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4h-1-benzopyran-4-on
3,5,7,2’,4’-pentahydroxyflavonol
abcolfustic
al-morin
boisd’arc
zlutprirodni11
MorinGr-(2'3,4',5,7-Pentahydroxyflavone)
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy- | [EINECS(EC#)]
207-542-9 | [Molecular Formula]
C15H10O7 | [MDL Number]
MFCD00006826 | [Molecular Weight]
302.24 | [MOL File]
480-16-0.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to brown powder | [Melting point ]
299-300 °C (dec.)(lit.)
| [Boiling point ]
363.28°C (rough estimate) | [density ]
1.3616 (rough estimate) | [refractive index ]
1.4790 (estimate) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
methanol: 50 mg/mL
| [Colour Index ]
75660 | [form ]
powder
| [pka]
6.30±0.40(Predicted) | [color ]
yellow
| [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
0.25g/L(20 ºC) | [Merck ]
6269 | [InChIKey]
YXOLAZRVSSWPPT-UHFFFAOYSA-N | [LogP]
1.27-1.54 at 37℃ and pH7.4 | [CAS DataBase Reference]
480-16-0(CAS DataBase Reference) | [EPA Substance Registry System]
Morin (480-16-0) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3
| [RTECS ]
LK8749000 | [F ]
8-10-23 | [HS Code ]
29329990 | [Safety Profile]
Moderately toxic by
intraperitoneal route. Mutation data
reported. When heated to decomposition it
emits acrid smoke and irritating fumes. | [Toxicity]
LD50 intraperitoneal in mouse: 555mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
yellow to brown powder | [Uses]
Morin is a natural pentahydroxyflavonol with antioxidant activity. It reduces CD36 expression and oxLDL uptake in U937-derived macrophages, inhibits PIM-1 kinase in vitro (IC50 = 2.7 μM), and reduces the activity of cytochrome P450 isoform 3A4 in liver microsomes. Through these and other actions, morin has anti-oxidant, anti-inflammatory, and other actions in animal models.[Cayman Chemical] | [Uses]
P450 and ATPase inhibitor | [Definition]
ChEBI: A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5. | [Purification Methods]
Stir morin at room temperature with ten times its weight of absolute EtOH, then leave overnight to settle. Filter it off, and evaporate under a heat lamp to one-tenth its volume. An equal volume of water is added, and the precipitated morin is filtered off, dissolved in the minimum amount of EtOH and again precipitated with an equal volume of water. The precipitate is filtered off, washed with water and dried at 110o for 1hour (yield ca 2.5%.). [Perkins & Kalkwarf Anal Chem 28 1989 1956.] It complexes with W and Zr. [Beilstein 18 H 239, 18 III/IV 3468, 18/5 V 492.] |
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