| Identification | More | [Name]
N-Boc-O-Benzyl-D-serine | [CAS]
47173-80-8 | [Synonyms]
BOC-D-SER(BZL)
BOC-D-SER(BZL)-OH
BOC-D-SERINE(BZL)-OH
BOC-L-SER(BZL)
BOC-L-SER(BZL)-OH
BOC-L-SERINE (BZL)
BOC-O-BENZYL-D-SERINE
BOC-O-BENZYL-L-SERINE
BOC-(R)-2-AMINO-3-BENZYLOXYPROPIONIC ACID
BOC-(S)-2-AMINO-3-BENZYLOXYPROPIONIC ACID
BOC-SER(BZL)
BOC-SER(BZL)-OH
BOC-SERINE(BZL)-OH
n-[(1,1-dimethylethoxy)carbonyl]-o-(phenylmethyl)-l-serine
N-ALPHA-T-BOC-O-BENZYL-D-SERINE
N-ALPHA-T-BOC-O-BENZYL-L-SERINE
N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-L-SERINE
N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-D-SERINE
N-ALPHA-TERT-BOC-O-BENZYL-L-SERINE
N-ALPHA-TERT-BUTYLOXYCARBONYL-O-BENZYL-D-SERINE | [EINECS(EC#)]
245-820-1 | [Molecular Formula]
C15H21NO5 | [MDL Number]
MFCD00038248 | [Molecular Weight]
295.33 | [MOL File]
47173-80-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystalline powder | [Melting point ]
58-60 °C(lit.)
| [alpha ]
-19 º (c=2 80% alcohol) | [Boiling point ]
437.02°C (rough estimate) | [density ]
1.1454 (rough estimate) | [refractive index ]
-20 ° (C=2, 80% EtOH) | [storage temp. ]
2-8°C
| [solubility ]
almost transparency in Methanol | [form ]
Powder | [pka]
3.53±0.10(Predicted) | [color ]
White | [BRN ]
2665080 | [InChI]
InChI=1S/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)10-20-9-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,19)(H,17,18)/t12-/m1/s1 | [InChIKey]
DMBKPDOAQVGTST-GFCCVEGCSA-N | [SMILES]
C(O)(=O)[C@@H](COCC1=CC=CC=C1)NC(OC(C)(C)C)=O | [CAS DataBase Reference]
47173-80-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29242990 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder | [Uses]
N-BOC-O-Benzyl-D-serine, is an amino acid derivative used in chemical synthesis and peptide chemistry.is used in preparation of substituted naphthyl thiadiazolidinones as protein tyrosine phosphatase degraders for treating cancer and metabolic diseases. | [Synthesis]
N-Boc D-Se (500 mg, 2.43 mmol) dissolved in anhydrous DMF (4 mL) was slowly added to a dispersion of 60% NaH (204 mg, 5.1 mmol) in anhydrous DMF at 0 ° C. Stir the mixture at room temperature for 1 hour and cool to 0 ° C. Subsequently, benzyl bromide (0.29 mL, 2.43 mmol) was added and the mixture was heated to room temperature. After 4 hours of reaction, add saturated NH4Cl (1 mL) to quench the reaction. Finally, the product Boc-D-Ser(Bzl)-OH was obtained through purification. |
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