| Identification | Back Directory | [Name]
Timosaponin A-III | [CAS]
41059-79-4 | [Synonyms]
Filiferin B
XilingsaponinA
TIMOSAPONIN A-
AnemarsaponinA3
TIMOSAPONIN A-3
Timosaponin A-III
Timosaponine A III
Timosaponin A-Ⅲ Standard
TIMOSAPONIN A3 (SYN. TIMOSAPONIN A-III)
β-D-Galactopyranoside, (3β,5β,25S)-spirostan-3-yl2-O-β-D-glucopyranosyl-
[(25S)-5β-Spirostan-3β-yl]2-O-(β-D-glucopyranosyl)-β-D-galactopyranoside
(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((2aR,2'R,4S,6aS,6bS,8aS,8bR,9S,11aS,12aS,12bR)-5',6a,8a,9-tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | [Molecular Formula]
C39H64O13 | [MDL Number]
MFCD01631164 | [MOL File]
41059-79-4.mol | [Molecular Weight]
740.92 |
| Chemical Properties | Back Directory | [Melting point ]
317-322 °C | [Boiling point ]
862.8±65.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml | [form ]
White to off white solid. | [pka]
12.85±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Induces autophagy in HeLa cells followed by apoptotic cell death (IC50=10μM). This cellular response has been found to be mediated via inhibition of mTORC1 and induction of ER stress (IC50 for BT474 cells=2.5μM and MDAMB231 cells=6μM). The pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both. |
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