| Identification | More | [Name]
Potassium bis(trimethylsilyl)amide | [CAS]
40949-94-8 | [Synonyms]
1,1,1,3,3,3-HEXAMETHYLDISILAZANE POTASSIUM SALT
HEXAMETHYLDISILAZANE POTASSIUM SALT
HEXAMETHYLDISLAZANE POTASSIUM SALT
KHMDS
POTASSIUM BIS(TRIMETHYLSILYL)AMIDE
POTASSIUMHEXAMETHYLDISILAZANE
POTASSIUM HEXAMETHYLDISILAZIDE
POTASSIUM HEXAMETHYLDISLAZANE
HexamethyldisilazanePotassiumSalt(15%inToluene)
potassiumhexamethyldisilazane(solutioninthf)
potassiumhexamethyldisilazane,khmds,in
potassiumhexamethyldisilazane,khmds,intetrahydrofuran
potassiumhexamethyldisilazane,khmds,intoluene
KHMDS~Potassium hexamethyldisilazide
Potassium hexamethyldisilazane, in tetrahydrofuran
Potassium hexamethyldisilazane, in toluene
POTASSIUM BIS(TRIMETHYLSILYL)AMIDE SOL., ~0.5 M IN TOLUENE
POTASSIUM BIS(TRIMETHYLSILYL)AMIDE, 0.5M SOLUTION IN TOLUENE
POTASSIUM BIS(TRIMETHYLSILYL)AMIDE, DRY POWDER
PotassiumhexamethyldislazaneinTHF | [EINECS(EC#)]
424-100-2 | [Molecular Formula]
C6H18KNSi2 | [MDL Number]
MFCD00010330 | [Molecular Weight]
199.48 | [MOL File]
40949-94-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to amber solution | [Melting point ]
194-195°C | [Boiling point ]
111 °C | [density ]
0.877 g/mL at 25 °C
| [vapor density ]
3.2 (vs air)
| [vapor pressure ]
54 mm Hg ( 25 °C)
| [refractive index ]
1.4920 | [Fp ]
45 °F
| [storage temp. ]
Refrigerator | [solubility ]
Miscible with terahydrofuran, ether, benzene and toluene. | [form ]
Liquid | [color ]
clear to slightly hazy yellow | [Specific Gravity]
0.877 | [Water Solubility ]
Reacts with water. | [Hydrolytic Sensitivity]
8: reacts rapidly with moisture, water, protic solvents | [Sensitive ]
Moisture Sensitive | [Detection Methods]
T | [BRN ]
4006754 | [CAS DataBase Reference]
40949-94-8(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen | [EPA Substance Registry System]
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt (1:1) (40949-94-8) |
| Safety Data | Back Directory | [Hazard Codes ]
C,F | [Risk Statements ]
R14:Reacts violently with water.
R34:Causes burns.
R67:Vapors may cause drowsiness and dizziness.
R65:Harmful: May cause lung damage if swallowed.
R63:Possible risk of harm to the unborn child.
R48/20:Harmful: danger of serious damage to health by prolonged exposure through inhalation .
R11:Highly Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S62:If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S46:If swallowed, seek medical advice immediately and show this container or label .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 3263 8/PG 3
| [WGK Germany ]
3
| [F ]
1-3-10 | [TSCA ]
No | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29319090 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to amber solution | [Uses]
Potassium Bis(trimethylsilyl)amide (1M in THF) is used in the preparation of 5-azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions. | [Uses]
Potassium bis(trimethylsilyl)amide is a strong base used in the alkylation carbonyl compounds.1
| [Uses]
Potassium Hexamethyldisilazide is widely used as a Sterically Hindered Base for Enolate Generation in Selective Formation of Linear Conjugated Dienolates and Alkyl (Z)-3-Alkenoates. | [Preparation]
Potassium Hexamethyldisilazide is prepared and isolated by the procedure
of Wannagat and Niederpruem. A more convenient in situ
generation from potassium hydride and hexamethyldisilane is
described by Brown. | [General Description]
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product, 1.0 M in 2-methyltetrahydrofuran aligns with "Safer Solvents and Auxiliaries", "Use of Renewable Feedstocks" and "Inherently Safer Chemistry for Accident Prevention". Click here for more information. |
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