| Identification | More | [Name]
5-Fluoro-2-methylindole | [CAS]
399-72-4 | [Synonyms]
5-FLUORO-2-METHYL-1H-INDOLE
5-FLUORO-2-METHYLINDOLE | [EINECS(EC#)]
609-764-5 | [Molecular Formula]
C9H8FN | [MDL Number]
MFCD02093649 | [Molecular Weight]
149.16 | [MOL File]
399-72-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
98-101 °C (lit.) | [Boiling point ]
112-120C | [density ]
1.219±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Solid | [pka]
16.73±0.30(Predicted) | [color ]
Light yellow to Brown | [InChI]
InChI=1S/C9H8FN/c1-6-4-7-5-8(10)2-3-9(7)11-6/h2-5,11H,1H3 | [InChIKey]
JJIUISYYTFDATN-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=C(F)C=C2)C=C1C | [CAS DataBase Reference]
399-72-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,T | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R25:Toxic if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
2933998090 |
| Hazard Information | Back Directory | [Description]
5-Fluoro-2-methylindole is a chemical intermediate that can be used in the synthesis of other compounds. It is a versatile building block with many applications, such as being a useful intermediate for the synthesis of heterocyclic compounds. This compound reacts with aniline to form 2,6-diaminopyridine, which has been shown to have anti-inflammatory properties. | [General Description]
5-Fluoro-2-methylindole (5-Fluoro-2-methyl-1H-indole) is a 5-substituted-2-methyl-1H-indole. | [Synthesis]
1-(5-fluoro-2-nitrophenyl) propane-2-one (0.5mmol, 99 mg), zinc powder (3.0mmol, 196 mg), and acetic acid (6.0mmol, 360 mg) was added to the reaction tube, followed by adding ethanol to 2 ml at 90 °C for 3h. After cooling to room temperature, the reaction system was added 20 ml water. 5-Fluoro-2-methylindole was obtained after purification.  | [Solubility in water]
Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform, Practically insoluble in water. |
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