| Identification | Back Directory | [Name]
Todralazine hydrochloride | [CAS]
3778-76-5 | [Synonyms]
binazin
binazine
apirachol
Apiracohl
Hydrapron
ECARAZINE
TODRALAZINE HCL
621-bthydrochloride
ECARAZINE HYDROCHLORIDE
TODRALAZINE HYDROCHLORIDE
Todralazine hydrochloride hydrate
ethyl 3-(phthalazin-1-yl)carbazate hydrochloride
ethyl N-(phthalazin-1-ylamino)carbamate hydrochloride
ethyl 2-(phthalazin-1-yl)hydrazinecarboxylate hydrochloride
carbazicacid,3-(1-phthalazinyl)-,ethylester,monohydrochloride
N-(phthalazin-1-ylamino)carbamic acid ethyl ester hydrochloride
2-(1-PHTHALAZINYL)-HYDRAZINECARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
hydrazinecarboxylicacid,2-(1-phthalazinyl)-,ethylester,monohydrochloride | [Molecular Formula]
C11H13ClN4O2 | [MDL Number]
MFCD00057321 | [MOL File]
3778-76-5.mol | [Molecular Weight]
268.7 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): slightly | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Originator]
Prorazin,Teisan | [Uses]
Antihypertensor | [Manufacturing Process]
A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol
is cooled, under agitation to a temperature of -10°C. To the suspension is
added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in
150 ml of anhydrous ethanol and the reaction mass is agitated for about 2
hours, maintaining a temperature of -10°C. The temperature is then raised to
about 20°C and stirring is continued for 2 hours, whereupon heating is applied
and boiling is maintained for 15 min. After cooling, the separated 1-
hydrazinophthalazine hydrochloride is filtered and washed with anhydrous
ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a
temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a
boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water,
and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature
of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and
washed with anhydrous ethanol. 11.5 g of a raw product are obtained which
for the purpose of purification are dissolved in 15 ml of boiling water with an
addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1-
carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are
obtained.
| [Therapeutic Function]
Antihypertensive |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|