| Identification | More | [Name]
5-Amino-2,4,6-triiodisophthaloyl acid dichloride | [CAS]
37441-29-5 | [Synonyms]
5-amino-2,4,6-triiodisophthaloyl acid dichloride
5-AMINO-2,4,6-TRIIODO-ISOPHTALOYL DICHLORIDE
5-AMINO-2,4,6-TRIIODOISOPHTHALOYL DICHLORIDE
5-amino-2,4,6-triodoisophthalolylchloride
5-Amino-2,4,6-Triiodoiso Phthaloyl Chloride
5-Amino-2,4,6-triiodisophthaloyl dichloride
5-Amino-2,4,6-Triiodo-1,3-Benzenedicarboxylic Acid Dichloride
5mino-2,4,6-TriiodoisophthalicAcidDichloride
5-Amino-2,4,6-triiodoisophthaloydichloride
5-Amino-2,4,6-Triodoisophthalo
5-AMINO-2,4,6-TRIIODOISOPHTALOYL CHLORIDE
5-amino-2,4,6-triodoisophthalolyl chloride 5-Amino-2,4,6-triiodo-1,3-benzenedicar-boxylic acid dichloride
5-amino-2,4,6-triiodo-1,3-benzenedicarbonyldichloride
2,4,6-Triodo-5-Amino Isophthaloyl Chloride (ATIPA DICHLORIDE) | [EINECS(EC#)]
417-220-1 | [Molecular Formula]
C8H2Cl2I3NO2 | [MDL Number]
MFCD00270836 | [Molecular Weight]
595.73 | [MOL File]
37441-29-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
231°C(lit.) | [Boiling point ]
566.9±50.0 °C(Predicted) | [density ]
2.826±0.06 g/cm3(Predicted) | [vapor pressure ]
0.018Pa at 20℃ | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
Acetone (Slightly), Methanol (Very Slightly) | [form ]
Solid | [pka]
-3.45±0.10(Predicted) | [color ]
Yellow toDark Brown | [λmax]
233nm(MeOH)(lit.) | [LogP]
3.7 at 20℃ | [CAS DataBase Reference]
37441-29-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
R43:May cause sensitization by skin contact.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
3077 | [HS Code ]
2922.49.3700 | [HazardClass ]
9 | [PackingGroup ]
III |
| Hazard Information | Back Directory | [Description]
5-Amino-2,4,6-triiodisophthaloyl acid dichloride is a triiodinated compound that has been shown to bind to the receptor for asialoglycoprotein. It is used in the diagnosis of liver and kidney diseases. 5-Amino-2,4,6-triiodisophthaloyl acid dichloride is taken up by tissues and organs and causes damage to these tissues. The chloride ion binds to the molecule, making it more water soluble. The lactobionic acid residue is then cleaved off by an enzyme in the cell called beta-galactosidase. This leaves a molecule containing iodine which can be detected with a diagnostic technique such as X-ray crystallography or nuclear magnetic resonance spectroscopy. | [Chemical Properties]
Yellow Solid | [Uses]
5-Amino-2,4,6- triiodisophthaloyl acid dichloride is used in the preparation of trimeric X-ray contrast agents.
| [Preparation]
5-Amino-2,4,6-triiodo-isophtalic acid (30 g, 0.054 mol), thionyl chloride (8.2 ml, 0.113 mol) and pyridine (0.2 ml) in 1 ,2 dichloroethane (20 ml) were heated to 70 ℃. A portion of thionyl chloride (15.2 ml, 0.21 mol) was added dropwise during 2 h, and the mixture was heated to 85 ℃ for 6 h. After cooling the reaction mixture to room temperature, it was poured into 300 g of ice-water. The yellow precipitate was filtered off, sucked dry and then washed with water until pH=5. The filter cake was then dried in a vacuum oven for 3 hrs. A light yellow powder was obtained as 5-Amino-2,4,6-triiodisophthaloyl acid dichloride.
 | [Flammability and Explosibility]
Notclassified |
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