| Identification | More | [Name]
4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE | [CAS]
37067-30-4 | [Synonyms]
4'-METHYLUMBELLIFERYL-2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE
4-METHYLUMBELLIFERYL-2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE
4-METHYLUMBELLIFERYL-2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOSE
4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE
4-MU-BETA-D-GLCNAC
7-HYDROXY-4-METHYLCUMARIN-N-ACETYL-BETA-D-GLUCOSAMINID
GLCNAC1-B-4MU
GLCNAC1-BETA-4MU
7-[[2-(acetylamino)-2-deoxy-beta-d-glucopyranosyl]oxy]-2h-1-benzopyran-2-on
7-[[2-acetamido-2-deoxy-beta-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one
4'-Methylumbelliferyl-2-acetamido-2-deoxy-b-D-glucopyranoside
4-METHYLUMBELLIFERYL-N-ACETYL-B-D-*GLUCO SAMINIDE CR
4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLU COSAMINIDE DIHY.
4-Methylumbelliferyl-N-acetyl-beta-D-
4-Methylumbelliferyl-N-acetyl-D-glucosaminide GlcNAc1-b-4MU
Methylumbelliferyl-N-acetyl-b-D-glucosaminide
4-methylumbelliferyl n-acetyl-β-d-glucosaminide dihydrate
4-METHYLUMBELLIFERYL-2-ACETAMIDO-2-DEOXY-SS-D-GLUCOPYRANOSIDE
4-methylumberiferryl-N-acetyl-beta-D-glucosaminide.2H2O
2-Oxo-4-methyl-2H-1-benzopyran-7-yl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside | [EINECS(EC#)]
253-333-0 | [Molecular Formula]
C18H21NO8 | [MDL Number]
MFCD00065481 | [Molecular Weight]
379.36 | [MOL File]
37067-30-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
208-210 °C | [Boiling point ]
507.24°C (rough estimate) | [density ]
1.4163 (rough estimate) | [refractive index ]
1.5740 (estimate) | [storage temp. ]
−20°C
| [solubility ]
DMF: 20 mg/mL, clear, colorless
| [form ]
Crystalline solid | [pka]
12.87±0.70(Predicted) | [color ]
White to Off-White | [Usage]
Fluorogenic substrate used for the assay of b-Acetylglucosaminidase. A fluorogenic substrate used for the diagnosis of GM2 gangliosidoses in leukocytes. Genetic defects in human b-hexosaminidase isozymes (Hex A & Hex B) result in various clinical an | [λmax]
360nm(Phosphate buffer sol.)(lit.) | [BRN ]
1693397 | [Stability:]
Light Sensitive - Protect from Light | [LogP]
0.340 (est) | [CAS DataBase Reference]
37067-30-4(CAS DataBase Reference) | [EPA Substance Registry System]
2H-1-Benzopyran-2-one, 7-[[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]oxy]-4-methyl- (37067-30-4) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [F ]
10-21 | [HS Code ]
29321900 |
| Hazard Information | Back Directory | [Chemical Properties]
4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE is White Crystalline Solid
| [Uses]
4-Methylumbelliferyl N-acetyl-β-D-glucosaminide has been used as a substrate for assaying
- β-N-acetylglucosaminidase (NAGase) from soil samples
- chitinase from Fusarium oxysporum using fluorimetric assay
- β-N-acetylhexosaminidases from Arabidopsis thaliana roots and leaves samples
| [Uses]
4-METHYLUMBELLIFERYL-N-ACETYL-BETA-D-GLUCOSAMINIDE is used for the assay of b-Acetylglucosaminidase. A fluorogenic substrate used for the diagnosis of GM2 gangliosidoses in leukocytes. Genetic defects in human b-hexosaminidase isozy mes (Hex A & Hex B) result in various clinical and biochemical types of GM2 gangliosidosis. They include Tay Sachs disease, Sandhoff disease and other forms. Fluorescence: max. Abs. l = 325nm, max. Em. l = 378nm
| [General Description]
4-Methylumbelliferyl N-acetyl-β-D-glucosaminide (4-MUF-NAG) contains chitin monomer, N-acetyl-D-glucosamine (NAG) and a 4-methylumbelliferone (7-hydroxy-4-methylcoumarin) (4-MUF) moiety. | [Biochem/physiol Actions]
4-Methylumbelliferyl N-acetyl-β-D-glucosaminide (4-MUF-NAG) is a synthetic fluorogenic substrate for N-acetyl-β-D-glucosaminidase (NAGase). The enzyme functionality is assessed by its ability to hydrolyze the N-acetyl-D-glucosamine (NAG) residue in 4-MUF-NAG. 4-MUF-NAG is also a substrate for Chitinase and N-acetylhexosaminidase. |
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