| Identification | More | [Name]
METHYL 3-METHOXY-4-METHYLBENZOATE | [CAS]
3556-83-0 | [Synonyms]
3-METHOXY-4-METHYLBENZOIC ACID METHYL ESTER
3-METHOXY-P-TOLUIC ACID METHYL ESTER
4-METHYL-M-ANISIC ACID METHYL ESTER
METHYL 3-METHOXY-4-METHYLBENZOATE
METHYL 3-METHOXY-P-TOLUATE
METHYL 4-METHYL-M-ANISATE
3-Methoxy-4-methyl-benzoesuremethylester
4-METHOXY-3-METHYLBENZOIC ACID METHYL ESTER
Methyl 3-methoxy-4-methylbenzoate, 98+% | [EINECS(EC#)]
609-142-3 | [Molecular Formula]
C10H12O3 | [MDL Number]
MFCD00082710 | [Molecular Weight]
180.2 | [MOL File]
3556-83-0.mol |
| Questions And Answer | Back Directory | [Preparation]
Methyl 3-methoxy-4-methylbenzoate is synthesized by the following steps:A mixture of methyl 3-hydroxy-4-methylbenzoate 36 (25 g, 0.151 mol), Me2SO4 (28.3 ml, 0.386 mol), anhydrous K2CO3 (103.5 g, 0.75 mol) was refluxed in acetone for 2 hours. K2CO3 was filtered off, washed thoroughly with acetone. The filtrates were combined and concentrated, the residue was redissolved in EtOAc washed with water, dried (anhydrous Na2SO4), filtered and concentrated in vacuo to furnish a white solid (19.52 g). Yield : 72%. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
1
| [HS Code ]
29189900 |
| Hazard Information | Back Directory | [Chemical Properties]
White low melting solid | [Uses]
Methyl 3-Methoxy-4-methylbenzoate has been used as a reactant in the preparation of an antimalaria drug that consists of the 4-aminoquinoline pharmacophore of chloroquine with clotrimazole-based antimalarials. | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 33, p. 1771, 1990 DOI: 10.1021/jm00168a036 | [General Description]
Methyl 3-methoxy-4-methylbenzoate can be prepared by reacting diazomethane with 3-methoxy-4-methylbenzoic acid in ether. |
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