| Identification | More | [Name]
CYCLOCREATINE | [CAS]
35404-50-3 | [Synonyms]
CYCLOCREATINE
2-IMINO-1-IMIDAZOLIDINEACETIC ACID
1-Carboxymethyl-2-iminoimidazolidin
1-CARBOXYMETHYL-2-IMINOIMIDAZOLIDINE
(2-Iminoimidazolidin-1-yl)acetic acid
2-Imino-1-imidazolidineacetic acid 98%
2-(2-Iminoimidazolidin-1-yl)acetic acid
2-Amino-4,5-dihydro-1H-Imidazole-1-acetic Acid
1H-Imidazole-1-aceticacid, 2-amino-4,5-dihydro-
Cyclocreatine, 1-Carboxymethyl-2-iminoimidazolidine
CyclocreatineQ: What is
Cyclocreatine Q: What is the CAS Number of
Cyclocreatine Q: What is the storage condition of
Cyclocreatine Q: What are the applications of
Cyclocreatine | [Molecular Formula]
C5H9N3O2 | [MDL Number]
MFCD00134455 | [Molecular Weight]
143.14 | [MOL File]
35404-50-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
322-326?C | [storage temp. ]
-20°C Freezer | [solubility ]
1 M HCl: soluble25mg/mL, clear, colorless | [form ]
Solid | [color ]
White to Off-White | [Usage]
Can regulate creatine biosynthesis by suppressing the level of arginine:glycine amidinotransferase in chick liver | [InChIKey]
AMHZIUVRYRVYBA-UHFFFAOYSA-N | [CAS DataBase Reference]
35404-50-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
2940000080 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Can regulate creatine biosynthesis by suppressing the level of arginine:glycine amidinotransferase in chick liver | [Uses]
Cyclocreatine is used to regulate creatine biosynthesis by suppressing the level of arginine:glycine amidinotransferase in chick liver. | [Biological Activity]
Creatine analog th at protects tissues from ischemic damage; decreases the rate of ATP production via creatine kinase and reduces the proliferation of tumor cell lines th at are characterized by high levels of creatine kinase expression. | [in vivo]
Cyclocreatine (500 mg/kg, i.v., a single dose for 60 min) restores heart contractile function and shows markedly less myocardial cell injury when compared to the control (saline) group in the acute myocardial infarction (AMI) intact dog model[1].
Cyclocreatine (0.28 mg/g, drink, supplementation daily from 10-week to 8 months) rescues microgliosis and clustering and moderates neurite dystrophy in TREM2?/? 5XFAD mice[2].
Cyclocreatine (40 mg, gavage, daily for 1 month) significantly reduces liver metastatic burden and affects prostate cancer progression in a model of liver metastasis of mice[3].
| Animal Model: | AMI-intact dog model[1] | | Dosage: | 500 mg/kg | | Administration: | i.v., a single dose for 60 min | | Result: | Preserved 85% of pre-ischemic ATP level (loss of only 15%) and 97% of the CrP (loss of 3%) during ischemia, as well as immediately restored over 80% of contractile function during the 2 h of reperfusion in AMI-intact dog model. |
| Animal Model: | 5XFAD and TREM2?/? 5XFAD mice | | Dosage: | 0.28 mg/g | | Administration: | Drinking water supplementation with cyclocreatine daily from 10-week to 8 months | | Result: | Improved microglial metabolism and the protective response to Aβ plaques in TREM2-deficient 5XFAD mice. |
| [storage]
4°C, protect from light |
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