| Identification | Back Directory | [Name]
alpha-Azido-omega-hydroxy octa(ethylene glycol) | [CAS]
352439-36-2 | [Synonyms]
PEG8-azide
N3-PEG(8)-OH
azido-PEG8-OH
Azido-dPEG??-OH
Azido-PEG (n=7)
Azido-PEG8-alcohol
Azide-PEG8-Alcohol
Azido-PEG7-alcohol
AZIDO-PEG8-HYDROXY
O-(2-Azidoethyl)heptaethylene glycol
alpha-Azido-omega-hydroxy octa(ethylene glycol)
3,6,9,12,15,18,21-heptaoxatricosan-1-ol,23-azide
23-Azido-3,6,9,12,15,18,21-Heptaoxatricosan-1-ol
3,6,9,12,15,18,21-Heptaoxatricosan-1-ol, 23-azido-
O-(2-Azidoethyl)heptaethylene glycol >=95% (oligomer purity)
2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol | [Molecular Formula]
C16H33N3O8 | [MDL Number]
MFCD08274607 | [MOL File]
352439-36-2.mol | [Molecular Weight]
395.45 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow | [α-end]
azide | [Ω-end]
hydroxyl | [BRN ]
8940056 |
| Hazard Information | Back Directory | [Description]
Azide-PEG8-alcohol is a click chemistry reagent with an azide(N3) and a terminal hydroxyl group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl (OH) group enables further derivatization or replacement with other functional groups. | [Uses]
O-(2-Azidoethyl)heptaethylene glycol is used to synthesize oligo and poly(ethylene glycol) derivatives that are used as structural units of dendrimers, hydrogels, surface modifiers, self-assembling systems and molecular crosslinkers. This precursor is compatible for acetylene-azide click reactions.
Some of the reported applications include:
- Synthesis of strain-stiffening hydrogels through self-assembly of oligomers fibres derived from Azido-PEG (n=7).
- Synthesis of biodegradable tetra-PEG hydrogels for drug delivery system.
- Synthesis of heterobifunctional oligo(ethylene glycol) linkers for bioconjugation and targeted drug delivery.
- Preparation of synthetic amphiphiles for programmed pH-dependent dispersions of carbon nanotubes (CNTs).
- Selective glycoprotein detection through allosteric click-imprinting by using a self-assembled monolayer developed from the above oligomer.
- Preparation of bioactivated quantum dot micelles containing fluorescent nanocrystals.
| [reaction suitability]
reaction type: click chemistry
reagent type: cross-linking reagent |
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