| Identification | More | [Name]
2-Propylpiperidine | [CAS]
3238-60-6 | [Synonyms]
2-N-PROPYLPIPERIDINE
2-PRIOPYLPIPERIDINE
2-PROPYLPIPERIDINE
CONIINE
CONIINE, DL-
(+/-)CONINE
DL-CONIINE
(2R)-2-Propylpiperidine
(R)-2-Propylpiperidine | [EINECS(EC#)]
221-801-3 | [Molecular Formula]
C8H17N | [MDL Number]
MFCD00056022 | [Molecular Weight]
127.23 | [MOL File]
3238-60-6.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2810 6.1/PG 2
| [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [Toxicity]
Piperidine alkaloid obtained
from poison hemlock, Conium maculatum. Alkaline, steam
volatile liquid (b.p. 167_x0003_C), mousy odor. Darkens and polymerizes
in air. It can be reduced at high temperature with HI
to n-octane and oxidized to pyridine-1-carboxylic acid. The
hydrochloride is used as an antispasmodic. |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid; darkens on exposure tolight and air; polymerizes; boils at 166°C(330.8°F); melts at -2°C (28.4°F); alkaline, pKa 3.1; density 0.845 at 20°C (68°F);slightly soluble in water and chloroform,readily soluble in most organic solvents. | [Uses]
Coniine is present in all parts of the plantpoison hemlock (Conium maculatum). It isthe first alkaloid to be synthesized and structure determined. Because of its high toxicity,its clinical application is very limited. | [Synthesis Reference(s)]
Tetrahedron Letters, 26, p. 4633, 1985 DOI: 10.1016/S0040-4039(00)98771-9 | [Health Hazard]
Coniine is a highly toxic alkaloid. Thetoxic symptoms from ingestion are weakness,drowsiness, nausea, vomiting, muscle contraction, and labored breathing. A high dosecan cause convulsions, cyanosis, asphyxia,and death. Chronic ingestion of coniine produced adverse reproductive effects and spe cific developmental abnormalities in cattles.LD50 value, oral (mice): 100 mg/kg. |
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