| Identification | More | [Name]
5-Fluoroisatonic anhydride | [CAS]
321-69-7 | [Synonyms]
5-FLUOROISATOIC ANHYDRIDE
6-FLUORO ISATIN ANHYDRIDE
6-FLUOROISATOIC ANHYDRIDE
5-FLUOROISATONIC ANHYDRIDE
6-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE | [EINECS(EC#)]
640-488-8 | [Molecular Formula]
C8H4FNO3 | [MDL Number]
MFCD03300719 | [Molecular Weight]
181.12 | [MOL File]
321-69-7.mol |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [HazardClass ]
IRRITANT | [HS Code ]
2934999090 |
| Hazard Information | Back Directory | [Chemical Properties]
Dark yellow Solid | [Uses]
5-Fluoroisatoic Anhydride is a versatile pharmaceutical intermediate used in the preparation of insulin secretagogues, HCV polymerase inhibitors, anxiolytic agents and other bioactive compounds. | [Preparation]
5-Fluoroisatonic anhydride is prepared from 5-fluoro indole (9d) by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
1 H NMR (DMSO-d6): δ11.19 (s, br., 1H), 7.36 (dd, J = 8.4, 2.6 Hz, 1H), 6.87 (dt, J = 8.4, 2.2 Hz, 1H), 6.74 (dd, J = 9.3, 2.2 Hz, 1H).
|
|
|