| Identification | More | [Name]
TAPS | [CAS]
29915-38-6 | [Synonyms]
[2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL]AMINO)-1-PROPANESULFONIC ACID
3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-1-propanesulfonic acid
3-[N-TRIS-(HYDROXYMETHYL)METHYLAMINO]-PROPANESULPHONIC ACID
3-[TRIS(HYDROXYMETHYL)METHYLAMINO]-1-PROPANESULFONIC ACID
3-[[TRIS(HYDROXYMETHYL)METHYL]AMINO]PROPANESULFONIC ACID
N-TRIS(HYDROXYMETHYL)METHYL-3-AMINOPROPANESULFONIC ACID
N-TRIS(HYDROXYMETHYL)METHYL-3-AMINOPROPANE-SULPHONIC ACID
TAP
TAPS
3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-1-propanesulfonicaci
tris(hydroxymethyl)methylaminopropansulfonic
tris(hydroxymethyl)methylaminopropansulfonicacid
3-(tris(hydroxymethyl)methylamino)propane-1-sulphonic acid
tris-Hydroxymethyl methylamino-3-propane sulfonic acid
TAPS FREE ACID, BIOTECHNOLOGY PERFORMANC E CERTIFIED
N-(TRIS(HYDROXYMETHYL)METHYL)-3-AMINO-PR OPANESULFONIC ACI
TAPS SIGMAULTRA
TAPS, MINIMUM 99.5% (TITRATION)
TAPS FREE ACID CRYSTALLINE
Taps3-[Tris(Hydroxymethyl)Methylamino]-1-PropanesulfonicAcid | [EINECS(EC#)]
249-954-1 | [Molecular Formula]
C7H17NO6S | [MDL Number]
MFCD00007538 | [Molecular Weight]
243.28 | [MOL File]
29915-38-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White/clear crystalline powder | [Melting point ]
230-235 °C (dec.)
| [density ]
1.4290 (rough estimate) | [refractive index ]
1.6370 (estimate) | [Fp ]
110 °C | [storage temp. ]
Store at RT. | [solubility ]
H2O: 1 M at 20 °C, clear, colorless
| [form ]
Solid | [pka]
8.55; pKa (37°): 8.1; pKa2 (25°): 8.28 | [color ]
White | [Odor]
Odorless | [PH Range]
7.7 - 9.1 | [Stability:]
Stable. Incompatible with strong oxidizing agents | [Water Solubility ]
Soluble | [Merck ]
13,9148 | [BRN ]
2452420 | [InChIKey]
YNLCVAQJIKOXER-UHFFFAOYSA-N | [CAS DataBase Reference]
29915-38-6(CAS DataBase Reference) | [EPA Substance Registry System]
29915-38-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29221980 |
| Hazard Information | Back Directory | [Description]
TAPS is a zwitterionic buffering agent used in biochemistry and molecular biology. It is part of the Tris family of buffers and is useful for a pH range of 7.7 – 9.1. The members of TRIS family are tris(hydroxymethyl)aminomethane (TRIS), N-[tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid (TES), N-[tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid (TAPS), N-[tris(hydroxymethyl)methyl]-3-amino-2-hydroxypropanesulfonic acid (TAPSO), and N-tris(hydroxymethyl)methyl-4-aminobutanesulfonic acid (TABS) buffers[1]. The solubilities of TAPS in aqueous solution decrease with increasing concentration of the salts (salting-out effect)[2]. TAPS is the preferred culture media buffer used for dinoflagellate experiments, allowing for minimal pH change and maximal growth. It is also often used in capillary electrophoresis to analyze DNA and in planar chromatography to separate dyes. TAPS may form a complex with some common metals so stability constants and concentrations should be taken into account when choosing this buffer. TAPS is capable of inhibiting connexin channels in animal cells. | [Chemical Properties]
White/clear crystalline powder | [Uses]
A zwitterionic Good's Buffer | [Application]
TAPS is a zwitterionic buffer used in biochemistry and molecular biology. It has a useful pH range of 7.7 - 9.1. TAPS has been utilized in capillary electrophoresis of DNA and DNA-dye complexes. Dyes can be separated by planar chromatography with electroosmotic flow containing 1 mM TAPS in the mobile phase. The stability constants of metal ions with TAPS have been investigated through the use of capillary electrophoresis. TAPS has also been shown to inhibit the activity of connexin channels. The activity of various carbonic anhydrases has been studied using TAPS physiological buffer, pKa = 8.4 at 20° C. | [Definition]
ChEBI: N-[tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid is an organosulfonic acid. | [References]
[1] Gupta B, et al. Stability Constants for the Equilibrium Models of Iron(III) with Several Biological Buffers in Aqueous Solutions. Journal of Solution Chemistry, 2013; 42: 2296–2309.
[2] Taha M, et al. New Insights into Buffer-Ionic Salt Interactions: Solubilities, Transfer Gibbs Energies, and Transfer Molar Volumes of TAPS and TAPSO from Water to Aqueous Electrolyte Solutions. Journal of Solution Chemistry, 2010; 39: 1665–1680. |
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