| Identification | More | [Name]
L-KYNURENINE | [CAS]
2922-83-0 | [Synonyms]
L-2-AMINO-3-(2-AMINOBENZOYL)PROPIONIC ACID
L-2-AMINO-4-[2-AMINOPHENYL]-4-OXOBUTANOIC ACID
L-KYNURENINE
L-kynurenine free base
β-Anthraniloyl-L-alanine
β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
L-Kynurenine Hydrate
(S)-2-Amino-4-oxo-4-(2-aminophenyl)butanoic acid
(S)-α,2-Diamino-γ-oxobenzenebutanoic acid
3-(2-Aminobenzoyl)alanine
3-(2-Aminobenzoyl)-L-alanine | [Molecular Formula]
C10H12N2O3 | [MDL Number]
MFCD00069912 | [Molecular Weight]
208.21 | [MOL File]
2922-83-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
219 °C | [Boiling point ]
466.6±45.0 °C(Predicted) | [density ]
1.343±0.06 g/cm3(Predicted) | [refractive index ]
-33 ° (C=0.4, H2O) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml). | [form ]
crystalline
| [pka]
2.21±0.23(Predicted) | [color ]
light yellow
| [Merck ]
5328 | [Stability:]
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. | [InChIKey]
YGPSJZOEDVAXAB-QMMMGPOBSA-N | [CAS DataBase Reference]
2922-83-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Kynurenine (2922-83-0) is a tryptophan catabolite.1?Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility.2 | [Uses]
L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay. It has also been used as a standard to extract and quantify kynurenine from cultured cells and media. | [Definition]
ChEBI: A kynurenine that has L configuration. | [Biochem/physiol Actions]
Key intermediate in the breakdown pathway of tryptophan. | [storage]
Store at RT | [References]
References/Citations
1) Ibana?et al. (2011),?Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlaydia trachomatis persistence in human epithelial cells; Infect. Immun.,?79?4425
2) Opitz?et al. (2011),?An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor; Nature,?478?197 |
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