| Identification | More | [Name]
Scutellarin | [CAS]
27740-01-8 | [Synonyms]
7-(beta-d-glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
SCUTELLAREIN 7-O-GLUCURONIDE
SCUTELLARIN
SCUTELLARIN, 98+% BY HPLC
(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl
β-D-Glucopyranosiduronicacid,5,6-dihydroxy-2-
4',5,6-Trihydroxy-7-[(β-D-glucopyranuronosyl)oxy]flavone
4',5,6-Trihydroxyflavon-7-yl β-D-glucopyranosiduronic acid
5,6-Dihydroxy-4-oxo-2-(4-hydroxyphenyl)-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid
Scutellarein 4'-methyl ether 7-glucuronide
Scutellarein 7-glucuronide | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C21H18O12 | [MDL Number]
MFCD01861503 | [Molecular Weight]
462.36 | [MOL File]
27740-01-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
300～301℃ | [Boiling point ]
891.6±65.0 °C(Predicted) | [density ]
1.810±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Very Slightly, Sonicated) | [form ]
neat | [pka]
2.72±0.70(Predicted) | [color ]
Light Yellow to Yellow | [BRN ]
71779 | [CAS DataBase Reference]
27740-01-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties.1,2,3 It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 μM, effects that can be blocked by the autophagy inhibitor HCQ (Item No. 17911).1 Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg.2 It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.3 | [Uses]
Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascula
r diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells. | [Definition]
ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein. |
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