| Identification | Back Directory | [Name]
Isoconazole | [CAS]
27523-40-6 | [Synonyms]
Isoconazol
soconazole
Isoconazole CRS
Einecs 248-508-3
Miconazole EP IMP D
24168-96-5 (Nitrate)
Miconazole Impurity D
Isoconazole USP/EP/BP
Miconazole EP Impurity D
Isoconazol [inn-spanish]
Miconazole Nitrate EP Impurity D
Isoconazole (Miconazole EP Impurity D)
Isoconazole (base and/or unspecified salts)
Miconazole Impurity 4(Miconazole EP Impurity D)
1-[β-[(2,6-Dichlorobenzyl)oxy]-2,4-dichlorophenethyl]-1H-imidazole
1-[2-(2,6-Dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]- (8CI)
1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole
Imidazole, 1-(2,4-dichloro-beta-((2,6-dichlorobenzyl)oxy)phenethyl)- (8ci)
1-[2-(2,4-Dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,6-dichlorophenyl)methoxy)ethyl)-
1-(2,4-Dichlorophenyl)-1-[(2,6-dichlorophenyl)methoxy]-2-(1H-imidazole-1-yl)ethane
1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]- (9CI)
Miconazole EP impurity DQ: What is
Miconazole EP impurity D Q: What is the CAS Number of
Miconazole EP impurity D Q: What is the storage condition of
Miconazole EP impurity D Q: What are the applications of
Miconazole EP impurity D | [EINECS(EC#)]
248-508-3 | [Molecular Formula]
C18H14Cl4N2O | [MOL File]
27523-40-6.mol | [Molecular Weight]
416.134 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white powder. | [Boiling point ]
555.1±50.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Practically insoluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent). | [form ]
neat | [pka]
6?+-.0.12(Predicted) | [CAS DataBase Reference]
27523-40-6 |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white powder. | [Uses]
Antibacterial; antifungal. | [Originator]
Fazol,Fournier,France,1979 | [Definition]
ChEBI: 1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1. It is a dichlorobenzene, an ether and a member of imidazoles. | [Manufacturing Process]
To a stirred and refluxing solution of 40 parts of benzene and 35 parts of
dimethylformamide (both solvents previously dried azeotropically) are added
successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4-
dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the
addition is complete, stirring and refluxing is continued for 30 minutes. Then
there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is
stirred at reflux for another 3 hours. The reaction mixture is poured onto
water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]
imidazole, is extracted with benzene. The extract is washed twice with water,
dried, filtered and evaporated in vacuo. The base residue is dissolved in a
mixture of acetone and diisopropyl ether and to this solution is added an
excess of concentrated nitric acid solution. The precipitated nitrate salt is
filtered off and recrystallized from a mixture of methanol and diisopropyl
ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole
nitrate; melting point 179°C. | [Therapeutic Function]
Antibacterial, Antifungal |
|
|