| Identification | More | [Name]
Alibendol | [CAS]
26750-81-2 | [Synonyms]
2-hydroxy-n-(2-hydroxyethyl)-3-methoxy-5-(2-propenyl)benzamide
ALIBENDOL
2-hydroxy-n-(2-hydroxyethyl)-3-methoxy-5-(2-propenyl)-benzamid
5-allyl-2-hydroxy-n-(2-hydroxyethyl)-3-methoxy-benzamid
5-allyl-2-hydroxy-n-(2-hydroxyethyl)-m-anisamid
Ailbendol
fc54
hydroxy-2methoxy-3allyl-5n-(beta-hydroxyethyl)benzamide
Alibendol ,2-hydroxy-3-methoxy-5-allyl-N-(C-hydroxyethyl)-benzamide
5-Allyl-2-hydroxy-N-(2-hydroxyethyl)-3-methoxybenzamide
5-Allyl-N-(2-hydroxyethyl)-3-methoxysalicylamide
Cebera
H-3774
PC-54 | [EINECS(EC#)]
247-960-9 | [Molecular Formula]
C13H17NO4 | [MDL Number]
MFCD00865165 | [Molecular Weight]
251.28 | [MOL File]
26750-81-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
97-99°C | [Boiling point ]
402.4±45.0 °C(Predicted) | [density ]
1.192±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO, Methanol | [form ]
Solid | [pka]
8.59±0.48(Predicted) | [color ]
White | [λmax]
316nm(EtOH)(lit.) | [Merck ]
14,244 | [CAS DataBase Reference]
26750-81-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [RTECS ]
CU8730000 | [HS Code ]
2924.29.7790 | [Toxicity]
LD50 in Swiss male mice (mg/kg): >3000 orally; >2000 s.c.; 209 i.p.; 217 i.v. (Clémence) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Originator]
Cebera ,Bouchara ,France ,1981 | [Uses]
Alibendol is an antispasmodic,choleretic, and cholekinetic.
| [Uses]
An amide analog of Eugenol, and is used therapeutically as an antispasmodic. | [Definition]
ChEBI:Alibendol is a member of salicylamides. | [Manufacturing Process]
36 g of ethyl ester of 2-hydroxy-3-methoxy-5-allyl-benzoic acid [obtained by
the process described by Pearl, et al., J. Amer. Chem. Soc., Vol. 71, 1067-
1068 (1949)] and 61 g of ethanolamine were admixed and left to stand for 1
hour at ambient temperature after which it was heated for 1 hour at 120°C.
The mixture was extracted with chloroform and the organic phases were
washed with half diluted hydrochloric acid, then with water, and the
chloroform evaporated off. The residue, after recrystallization from benzene,
was a 78% yield of 2-hydroxy-3-methoxy-5-allyl-N-(β-hydroxyethyl)-
benzamide having a melting point of 95°C. The product appeared in the form
of colorless crystals which were insoluble in water and soluble in dilute sodium
hydroxide. | [Therapeutic Function]
Choleretic, Spasmolytic | [storage]
Store at -20°C |
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