| Identification | More | [Name]
AURAMINE O | [CAS]
2465-27-2 | [Synonyms]
4,4'-(IMIDOCARBONYL)BIS(N,N-DIMETHYLANILINE) MONOHYDROCHLORIDE
AMINOTETRAMETHYL DIAMINODIPHENYLMETHANE
AURAMINE
AURAMINE HYDROCHLORIDE
AURAMINE O
AURAMINE O BASE
AURAMINE O FLUORESCENT STAIN
AURAMINE OS
AURAMINE SP
AURAMINE YELLOW
BASIC YELLOW 2
CANARY YELLOW
CI 41000
CI NO 41000
LABOTEST-BB LT00159440
PYKOTANNIN
PYOCTANINUM AUREUM
PYOCTANUNUM AUREUM
PYOKTANIN YELLOW
WAXOLINE YELLOW O | [EINECS(EC#)]
219-567-2 | [Molecular Formula]
C17H22ClN3 | [MDL Number]
MFCD00012484 | [Molecular Weight]
303.83 | [MOL File]
2465-27-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Auramine is a yellow crystalline powder or
flaky material. | [Melting point ]
>250 °C (dec.)(lit.) | [storage temp. ]
Store at RT. | [solubility ]
10g/l | [Colour Index ]
41000 | [form ]
Powder/Solid | [pka]
9.8, 10.7(at 25℃) | [color ]
Yellow to ochre-yellow | [PH]
6-7 (10g/l, H2O, 20℃) | [PH Range]
6.5 | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
Soluble in water or ethanol | [λmax]
370 nm, 432 nm | [BRN ]
4030061 | [Biological Applications]
Detecting bacteria; treatment of cancers,cardiovascular disease,diabetesassociated pain,mechanical allodynia,metabolic syndrome,protozoan infections in fish; targeted drug delivery; as fungal inhibitors | [CAS DataBase Reference]
2465-27-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Aniline, 4,4'-(imidocarbonyl)bis-(n,n-dimethyl)-, hydrochloride(2465-27-2) | [EPA Substance Registry System]
Auramine, monohydrochloride (2465-27-2) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xn | [Risk Statements ]
R22:Harmful if swallowed.
R24:Toxic in contact with skin.
R40:Limited evidence of a carcinogenic effect.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S22:Do not breathe dust . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
BY3675000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29215900 | [Hazardous Substances Data]
2465-27-2(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 1000 mg/kg |
| Hazard Information | Back Directory | [General Description]
Yellow flakes or powder. | [Reactivity Profile]
AURAMINE O(2465-27-2) is incompatible with strong oxidizing agents. | [Air & Water Reactions]
Insoluble in water. | [Hazard]
Probable carcinogen. | [Potential Exposure]
Auramine is used industrially as a dye
or dye intermediate for coloring textiles; paper, and leather.
Also used as an antiseptic (a powerful antiseptic in ear and
nose surgery, and treatment of gonorrhea) and fungicide.
Human exposure to auramine occurs principally through
skin absorption or inhalation of vapors. Low-level dermal
exposure to the consumer may occur but would be limited
to any migration of auramine from fabric, leather, or paper
goods. | [Fire Hazard]
Flash point data for this chemical are not available. AURAMINE O is probably combustible. | [First aid]
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration
with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and
isolate contaminated clothing and shoes. In case of contact
with substance, immediately flush skin or eyes with running
water for at least 20 minutes. For minor skin contact,
avoid spreading material on unaffected skin. Keep victim
warm and quiet. Effects of exposure (inhalation, ingestion
or skin contact) to substance may be delayed. Ensure that
medical personnel are aware of the material(s) involved
and take precautions to protect themselves. Medical observation
is recommended for 24 to 48 hours after breathing
overexposure, as pulmonary edema may be delayed. As
first aid for pulmonary edema, a doctor or authorized paramedic
may consider administering a drug or other inhalation
therapy. | [Shipping]
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. UN3143 Dyes, solid, toxic, n.o.s. or Dye
intermediates, solid, toxic, n.o.s., Hazard Class: 6.1;
Labels: 6.1-Poisonous materials, Technical Name Required. | [Incompatibilities]
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. | [Chemical Properties]
Auramine is a yellow crystalline powder or
flaky material. | [Chemical Properties]
yellow powder | [Waste Disposal]
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
Incinerate in furnace with afterburner and scrubber. | [Uses]
Certified for use by fluorescence microscopy in Churukian's modification of Truant's fluorescent method for acid fast bacilli on paraffin sections. | [Uses]
Fluorescent stain for acid-resistant bacteria in sputum | [Definition]
ChEBI: A hydrochloride obtained by combining 4,4'-carbonimidoylbis(N,N-dimethylaniline) with one molar equivalent of hydrogen chloride. A fluorescent stain for demonstrating acid fast organisms in a method similar to the Zieh
Neelsen. It also can be used to make a fluorescent Schiff reagent. | [Properties and Applications]
|
TEST ITEMS
|
SPECIFICATION
|
|
APPEARANCE
|
DARK YELLOWPOWDER
|
|
SHADE
|
BRIGHT YELLOWISH
|
|
HEAT RESISTANCE
|
280 °C min
|
|
DENSITY
|
1.07 g/cm
3
|
|
WATER FASTNESS
|
4-5
|
|
LIGHT FASTNESS
|
1-2
|
|
BLEACHABILITY (OXIDATIVE)
|
4
|
|
BLEACHABILITY (REDUCTIVE)
|
3
|
|
WATER SOLUBILITY AT
20
°C
|
10 g/L min
|
|
WATER INSOLUBLE
|
1.0% max
|
|
MOISTURE
|
3.0% max
|
|
TINTING STRENGTH
|
100-105 %
|
|
WEIGHT METAL TOTAL
|
50ppm max
|
| [Purification Methods]
It crystallises from EtOH as the hydrochloride and is very slightly soluble in CHCl3, UV: 434nm ( 370). The free base (carbinolamine) has m 136o (from *C6H6). [Goldacre & Phillips J Chem Soc 1724 1949, Conrad et al. Biochemistry 9 1540 1970, Beilstein 14 IV 256.] |
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