| Identification | More | [Name]
ACETYLCHOLINE IODIDE | [CAS]
2260-50-6 | [Synonyms]
2-ACETOXYETHYLTRIMETHYLAMMONIUM IODIDE
2-(ACETYLOXY)-N,N,N-TRIMETHYLETHANAMINIUM IODIDE
ACETYLCHOLINE IODIDE
ACH
N-(2-HYDROXYETHYL)TRIMETHYLAMMONIUM IODIDE ACETATE
2-(acetyloxy)-n,n,n-trimethyl-ethanamiuiodide
2-(acetyloxy)-n,n,n-trimethylethanamiumiodide
acetyl-choliniodide
acetylcolina
choline,iodide,acetate(ester)
cholineacetate(ester),iodide
(2-Hydroxyethyl)-trimethylammonium iodide acetate
Acetycholine iodide
(2-Acetoxyethyl)-trimethyammoniumiodide
Acetylcholine iodide
(2-Acetoxyethyl)-trimethyammoniumiodide
ACETYLCHOLINE IODIDE CRYSTALLINE
O-AcetylcholineIodide
Acetylchloineiodide
| [EINECS(EC#)]
218-862-3 | [Molecular Formula]
C7H16INO2 | [MDL Number]
MFCD00011815 | [Molecular Weight]
273.11 | [MOL File]
2260-50-6.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
KH3300000
| [F ]
8-9 | [TSCA ]
Yes | [HS Code ]
29239000 |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE CRYSTALLINE POWDER | [Uses]
Acetylcholine is an endogenous neurotransmitter at cholinergic synapses that amplifies action potential of the sarcolemma thereby inducing muscle contractions. Acetylcholine iodide is used as an acetylcholine receptor agonist to identify, characterize and differentiate among types of cholinergic receptors. Acetylcholine iodide is used as a substrate to identify and characterize natural and mutated acetylcholinesterase(s). | [Biochem/physiol Actions]
Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions. | [in vivo]
Acetylcholine iodide (3 μg; i.v.) increases the electrical potential difference in the proximal colon of rats[2].
Acetylcholine iodide (25 mg/kg; subcutaneous injection; twice a day; 15 days) induces mammary ductal growth in some virgin rats[3].
Acetylcholine iodide (25 mg/kg; subcutaneous injection; twice a day; 5 days) induces lobular-acinar growth and secretion in the mammary glands of virgin rats pretreated with estrogen[3].
| Animal Model: | Female albino rats (Carworth, weighing 175 - 200 g, age unspecified) for studying mammary growth and lactation induction; Female albino rats (Carworth, postparturient, litter removed on 4th day after parturition) for studying maintenance of mammary structure and secretion[3]. | | Dosage: | 25 mg/kg, 50 mg/kg (dissolved in an unspecified solvent for subcutaneous injection) | | Administration: | Subcutaneous injection, twice daily for 15 days (for induction in virgin rats), twice daily for 5 days after 10 days of estradiol pretreatment (for induction in estrogen-primed virgin rats), twice daily for 10 days (for maintenance in lactating rats after litter removal) | | Result: | Induced duct growth in some cases without estradiol priming, and lobule-alveolar growth and secretion with estradiol priming in virgin rats.
Retarded mammary involution and maintained lactation in lactating rats after litter removal.
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| [IC 50]
Human Endogenous Metabolite |
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