| Identification | Back Directory | [Name]
Polygalacic acid | [CAS]
22338-71-2 | [Synonyms]
Polygalacic
Virgaureagenin G
Polygalacic acid
Polygalacic acid, >=98%
(4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic acid, 98%, from Polygala tenuifolia Willd.
(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-
Polygalacic acid
(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
(4AR,5R,6aS,6bR,9R,10R,11S,12aR,12bR,14bR)-5,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12 | [Molecular Formula]
C30H48O6 | [MDL Number]
MFCD12911690 | [MOL File]
22338-71-2.mol | [Molecular Weight]
504.7 |
| Chemical Properties | Back Directory | [Melting point ]
300-305 °C (sublm) | [Boiling point ]
638.1±55.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.41±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Polygalacic acid can be used to calm the nerves, eliminate phlegm, reduce swelling, etc. It is mostly used clinically to treat bronchitis, induce labor, and induce labor. | [Biological Activity]
Polygalacic acid is a triterpenoid tetrahydroxy acid isolated from Polygala paenea L.. It (0-100μM; 24h) can significantly reduce the mRNA expression of MMP-3, MMP-9, MMP-13 and COX-2, and the expression of these factors can be significantly increased by IL-1β in a dose-dependent manner . | [in vitro]
Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a In a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid. RT-PCR | Cell Line: | Chondrocyte cells | | Concentration: | 50 μM; 100 μM | | Incubation Time: | 24 hours | | Result: | Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. | Western Blot Analysis | Cell Line: | Chondrocyte cells | < tr> Concentration: | 50 μM; 100 μM | | Incubation Time : | 6 hours | | Result: | Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes. | | [storage]
4°C, protect from light |
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