| Identification | More | [Name]
Chloromethyl chloroformate | [CAS]
22128-62-7 | [Synonyms]
CHLOROFORMIC ACID CHLOROMETHYL ESTER
CHLOROMETHYL CHLOROFORMATE
CMCF
JMC
chlorocarbonicacidchloromethylester
CHLOROMETHYL CHLOROFORMATE (JMC)(INTERMEDIATE OF TENOFOVIR DISOPROXIL FUMARATE)
Chloromethylchloroformate,97%
Chloromethyl Chloroformate (JMC)
Carbonochloridic acid chloromethyl ester
Chloromethoxycarbonyl chloride
Formic acid, chloro-, chloromethyl ester | [EINECS(EC#)]
244-793-3 | [Molecular Formula]
C2H2Cl2O2 | [MDL Number]
MFCD00077688 | [Molecular Weight]
128.94 | [MOL File]
22128-62-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
<-20°C | [Boiling point ]
107-108 °C(lit.) | [density ]
1.449 g/mL at 20 °C
| [refractive index ]
n20/D 1.428
| [Fp ]
95°C | [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Soluble), Methanol (Slightly) | [form ]
clear liquid | [color ]
Colorless to Light yellow to Light orange | [Water Solubility ]
Slightly miscible with water. | [Sensitive ]
Moisture Sensitive | [BRN ]
506426 | [Stability:]
Extremely Moisture Sensitive, Hygroscopic | [CAS DataBase Reference]
22128-62-7(CAS DataBase Reference) | [EPA Substance Registry System]
22128-62-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R23:Toxic by inhalation.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2745 6.1/PG 2
| [WGK Germany ]
3
| [F ]
10-19-21 | [HS Code ]
2915.90.5050 | [HazardClass ]
6.1 | [PackingGroup ]
II |
| Hazard Information | Back Directory | [General Description]
A colorless liquid with a penetrating, irritating odor. Denser than water. Contact may irritate skin, eyes and mucous membranes. Toxic by ingestion, inhalation and skin absorption. Used to make other chemicals. | [Reactivity Profile]
CHLOROMETHYLCHLOROFORMATE is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. | [Air & Water Reactions]
Reacts with moisture in air to generate heat and hydrochloric acid fumes [Merck, 11th ed., 1989]. Reacts with water. | [Health Hazard]
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Fire Hazard]
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Vapors may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. | [Chemical Properties]
Chloromethyl chloroformate is Clear Colourless Oil
| [Uses]
Chloromethyl chloroformate is used as a reagent in the synthesis of carbamates and carbonates.
| [Uses]
Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 106, p. 1808, 1984 DOI: 10.1021/ja00318a042 |
|