| Identification | More | [Name]
Hydroxyzine dihydrochloride | [CAS]
2192-20-3 | [Synonyms]
2-[2-[4-[(4-chlorophenyl)phenymethyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride
HYDROXYZINE DIHYDROCHLORIDE
HYDROXYZINE HYDROCHLORIDE
2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-ethanodihydroc
2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanoldihydrochl
2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-ethanodihydro
alamon
ataraxdihydrochloride
ataraxoiddihydrochloride
ateraxdihydrochloride
dichlorhydratede1-p.chlorbenzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine
neurolax
orgatrax
tran-qdihydrochloride
tranquizinedihydrochloride
vistarilsteraject
2-[2-[4-[(4-Chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]ethanol Dihydrochloride
Durrax
Quies
Ethanol, 2-2-4-(4-chlorophenyl)phenylmethyl-1-piperazinylethoxy-, dihydrochloride | [EINECS(EC#)]
218-586-3 | [Molecular Formula]
C21H29Cl3N2O2 | [MDL Number]
MFCD00058200 | [Molecular Weight]
447.83 | [MOL File]
2192-20-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
3
| [RTECS ]
KK2280000
| [HS Code ]
29335990 | [Toxicity]
LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Originator]
Atarax,UCB,France,1956 | [Uses]
Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats. | [Uses]
Anti histamines | [Uses]
Antihistaminic;H1 antogonist | [Uses]
H1 receptor antagonist. Anxiolytic. Antihistaminic. | [Manufacturing Process]
A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol
of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The
mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous
solution of NaOH; decanting takes place, and the benzene solution is washed
with water and the solvent is evaporated. Vacuum distilling of the residue
yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP
220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about
twice its weight of alcohol, by treating it with excess of gaseous HCl and by
precipitating it with ether. The solvent is decanted and the residue, dissolved
in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C. | [Brand name]
Amplimexon
(Amplimed). | [Therapeutic Function]
Tranquilizer | [General Description]
Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Biochem/physiol Actions]
Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery. | [storage]
4°C, protect from light |
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