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ChemicalBook--->CAS DataBase List--->191471-52-0

191471-52-0

191471-52-0 Structure

191471-52-0 Structure
IdentificationBack Directory
[Name]

LY 379268
[CAS]

191471-52-0
[Synonyms]

CS-1087
LY397268
LY 379268
(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid
2-Oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid,4-amino-,(1R,4R,5S,6R)-
[Molecular Formula]

C7H9NO5
[MDL Number]

MFCD11100365
[MOL File]

191471-52-0.mol
[Molecular Weight]

187.15
Chemical PropertiesBack Directory
[storage temp. ]

Store at +4°C
[solubility ]

Soluble in H2O or NaOH
[form ]

solid
[color ]

White
[Water Solubility ]

Soluble to 20 mM in water and to 100 mM in 1eq. NaOH
Hazard InformationBack Directory
[Uses]

LY 379268 is a group II metabotropic glutamate receptors (mGlu2/3) receptor agonist (1,2). Studies have shown that LY379268 significantly attenuated cocaine-induced increases in DA in nonhuman primates.
[Definition]

ChEBI: LY 379268 is an organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia. It has a role as a metabotropic glutamate receptor agonist, a neuroprotective agent, an antipsychotic agent and an anxiolytic drug. It is an organic heterobicyclic compound, a bridged compound and an amino dicarboxylic acid.
[Biological Activity]

Highly selective group II mGlu receptor agonist (EC 50 values are 2.69 and 4.48 nM for hmGlu 2 and hmGlu 3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active.
[storage]

Store at +4°C
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